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Guanghui Tian
Researcher at Chinese Academy of Sciences
Publications - 37
Citations - 1436
Guanghui Tian is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Sildenafil & Pharmacokinetics. The author has an hindex of 10, co-authored 35 publications receiving 985 citations. Previous affiliations of Guanghui Tian include East China University of Science and Technology.
Papers
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Journal ArticleDOI
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Wanchao Yin,Wanchao Yin,Chunyou Mao,Xiaodong Luan,Xiaodong Luan,Dan-Dan Shen,Qingya Shen,Haixia Su,Xiaoxi Wang,Fulai Zhou,Wenfeng Zhao,Minqi Gao,Shenghai Chang,Yuan Chao Xie,Guanghui Tian,He wei Jiang,Sheng-Ce Tao,Jingshan Shen,Yi Jiang,Hualiang Jiang,Yechun Xu,Shuyang Zhang,Yan Zhang,H. Eric Xu +23 more
TL;DR: Cryo–electron microscopy structures of the SARS-CoV-2 RdRp provide insights into the mechanism of viral RNA replication and a rational template for drug design to combat the viral infection.
Journal ArticleDOI
Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors
Zhijian Xu,Zheng Liu,Tong Chen,Tiantian Chen,Zhen Wang,Guanghui Tian,Jing Shi,Xuelan Wang,Yunxiang Lu,Xiuhua Yan,Guan Wang,Hualiang Jiang,Kaixian Chen,Shudong Wang,Yechun Xu,Jingshan Shen,Weiliang Zhu +16 more
TL;DR: X-ray crystal structures verified the existence of the predicted halogen bonds, demonstrating that the halogen bond is an applicable tool in drug design and should be routinely considered in lead optimization.
Posted ContentDOI
Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
Wanchao Yin,Wanchao Yin,Chunyou Mao,Xiaodong Luan,Xiaodong Luan,Dan-Dan Shen,Qingya Shen,Haixia Su,Xiaoxi Wang,Fulai Zhou,Wenfeng Zhao,Minqi Gao,Shenghai Chang,Yuan Chao Xie,Guanghui Tian,He wei Jiang,Sheng-Ce Tao,Jingshan Shen,Yi Jiang,Hualiang Jiang,Yechun Xu,Shuyang Zhang,Shuyang Zhang,Yan Zhang,H. Eric Xu +24 more
TL;DR: The structures of the SARS-CoV-2 RdRp provide critical insights into the working mechanism of viral RNA replication and a rational template for drug design to combat the viral infection.
Journal ArticleDOI
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2.
Journal ArticleDOI
2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.
Hongliang Duan,Jin Zheng,Qinglin Lai,Zheng Liu,Guanghui Tian,Zhen Wang,Jianfeng Li,Jingshan Shen +7 more
TL;DR: A novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6.