G
Guang-Jian Du
Researcher at University of Chicago
Publications - 27
Citations - 1373
Guang-Jian Du is an academic researcher from University of Chicago. The author has contributed to research in topics: Ginseng & Apoptosis. The author has an hindex of 18, co-authored 27 publications receiving 1209 citations. Previous affiliations of Guang-Jian Du include Sun Yat-sen University.
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Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea
TL;DR: Among the 10 polyphenols, EGCG showed the most potent antiproliferative effects, and significantly induced cell cycle arrest in the G1 phase and cell apoptosis, and the gallic acid group significantly enhanced catechin’s anticancer potential.
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Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells
Zhiyu Zhang,Chong-Zhi Wang,Guang-Jian Du,Lian-Wen Qi,Tyler Calway,Tong-Chuan He,Wei Du,Chun-Su Yuan +7 more
TL;DR: It is shown that isoflavones, especially genistein, could promote colon cancer cell growth inhibition and facilitate apoptosis and cell cycle arrest in the G2/M phase and the ATM/p53-p21 cross-regulatory network may play a crucial role in mediating the anticarcinogenic activities of genisteIn in colon cancer.
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Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng.
TL;DR: Red NG showed the best anticancer activity, due to the low cost of NG and high bioactivity of red NG, the red NG is promising to be a useful botanical product in cancer chemoprevention.
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Metabolism of ginseng and its interactions with drugs.
TL;DR: One ginseng metabolite, Compound K, and its potential for cancer chemoprevention is discussed, and an active ginsENG metabolite may differ in distribution and clearance from its parent compound, and the parent compound and its metabolites may be bioactive by similar or different mechanisms.
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Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer
Chong-Zhi Wang,Guang-Jian Du,Zhiyu Zhang,Xiao-Dong Wen,Tyler Calway,Zhong Zhen,Mark W. Musch,Marc Bissonnette,Eugene B. Chang,Chun-Su Yuan +9 more
TL;DR: C-K, but not its parent ginsenoside Rb1, showed significant anti-proliferative and pro-apoptotic effects in human colorectal cancer cells, suggesting that C-K could be a potentially effective anti-colorectAL cancer agent.