Guang Yang

TL;DR: In this article, the authors investigated the specific role of mtROS in initiating mitochondrial DNA (mtDNA) damage and inflammation during IRI-AKI, and they found that mt-ROS can promote renal injury by suppressing TFAM-mediated mtDNA maintenance, resulting in decreased mitochondrial energy metabolism and increased cytokine release.

TL;DR: It is concluded that injection of 80 mg/kg STZ could induce diabetes with moderate injuries and partial pancreatectomy with low-dose STZ is a safer and more reproducible method for inducing diabetes in rhesus monkeys.

TL;DR: It is suggested that increased serum metabolites, such as TMAO, lactate, branched-chain amino acids and decreased sphingomyelin and choline may serve as possible predictors for the evaluation of IGT and insulin resistance risks in the prediabetic state.

TL;DR: It is highlighted that NMR-based metabonomics provides insight into the underlying pathways in the pathogenesis and progression of DN at the metabolic level.

TL;DR: Overt and persistent diabetes can be induced in young rhesus monkeys by the injection of MLD-STZ, and autoimmune responses to pancreatic islet cells seem to be involved in the development of glucose intolerance and diabetes.