Yizhuo Wang

TL;DR: In this article, the authors investigated the specific role of mtROS in initiating mitochondrial DNA (mtDNA) damage and inflammation during IRI-AKI, and they found that mt-ROS can promote renal injury by suppressing TFAM-mediated mtDNA maintenance, resulting in decreased mitochondrial energy metabolism and increased cytokine release.

TL;DR: In this article, mesenchymal stem cells derived extracellular vesicles (MSC-EVs) were shown to attenuate mtDNA damage and inflammation after acute kidney injury (AKI) and that this effect was at least partially dependent on the mtDNA pathway.

TL;DR: An overview of macrophage and EV biology is introduced, primarily focusing on current findings and future perspectives with respect to the pathological and therapeutic effects of Mφ-EVs in various diseases.

TL;DR: Cytokine immunotherapy represents an attractive strategy to stimulate robust immune responses for renal injury repair in ischemic acute kidney injury (AKI), however, its clinical application is limited.

TL;DR: In this paper, the changes in BCAA catabolism, inflammation, organ damage, redox status, and mitochondrial function in db/db mice with treatments of BCAA-overload or BCAA activator were analyzed in vivo.