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Guang-zhi Qu
Researcher at Tulane University
Publications - 5
Citations - 636
Guang-zhi Qu is an academic researcher from Tulane University. The author has contributed to research in topics: DNA methylation & Satellite DNA. The author has an hindex of 5, co-authored 5 publications receiving 624 citations.
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Frequent Hypomethylation in Wilms Tumors of Pericentromeric DNA in Chromosomes 1 and 16
TL;DR: Methylation of normally highly methylated satellite DNA sequences in these regions in Wilms tumors found to be frequent in juxtacentromeric (satellite 2) sequences and, especially, in centromeric sequences of chromosome 1.
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DNA demethylation and pericentromeric rearrangements of chromosome 1.
Weizhen Ji,Raymundo Hernandez,Xian-Yang Zhang,Guang-zhi Qu,Allison Frady,Maria Quindós Varela,Melanie Ehrlich +6 more
TL;DR: It is hypothesized that demethylation in certain DNA regions, including in pericentromeric satellite DNA, helps lead to pericentroneric chromosomal rearrangements in lymphocytes from ICF patients and in normal lymphoblastoid cells incubated in vitro with DNA demethylating agents.
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Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential.
TL;DR: The findings are consistent with the hypothesis that one of the ways that genome-wide hypomethylation facilitates tumor development is that it often includes satellite hypometHylation which might predispose cells to structural and numerical chromosomal aberrations.
Journal Article
Frequent Detection of bcl-2/JH Translocations in Human Blood and Organ Samples by a Quantitative Polymerase Chain Reaction Assay
TL;DR: The findings suggest that some individuals who may be at risk for follicular lymphoma might be able to be identified by this PCR assay on peripheral blood, and may help explain the age dependence of the occurrence of this cancer.
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Demethylation and expression of methylated plasmid DNA stably transfected into HeLa cells
Guang-zhi Qu,Melanie Ehrlich +1 more
TL;DR: In vitro methylation of all CpGs in episomal or non-episomal plasmids containing the SV40 early promoter/enhancer driving expression of an antibiotic-resistance gene decreased the formation of antibiotic-resistant colonies by only approximately 30-45% upon stable transfection of HeLa cells.