M
Melanie Ehrlich
Researcher at Tulane University
Publications - 155
Citations - 14459
Melanie Ehrlich is an academic researcher from Tulane University. The author has contributed to research in topics: DNA methylation & DNA. The author has an hindex of 51, co-authored 151 publications receiving 13482 citations. Previous affiliations of Melanie Ehrlich include Stony Brook University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
DNA methylation in cancer: too much, but also too little.
TL;DR: The high frequency of cancer-linked DNA hypomethylation, the nature of the affected sequences, and the absence of associations with DNA hypermethylation are consistent with an independent role for DNA undermethylation in cancer formation or tumor progression.
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Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells
Melanie Ehrlich,Miguel A. Gama-Sosa,Lan Hsiang Huang,Rose Marie Midgett,Kenneth C. Kuo,Roy A. McCune,Charles W. Gehrke +6 more
TL;DR: Analysis of the total base composition of DNA from seven different normal human tissues and eight different types of homogeneous human cell populations revealed considerable tissue-specific and cell-specific differences in the extent of methylation of cytosine residues.
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DNA hypomethylation in cancer cells.
TL;DR: Evidence is accumulating for the biological significance and clinical relevance of DNA hypomethylation in cancer, and for cancer-linked demethylation and de novo methylation being highly dynamic processes.
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The 5-methylcytosine content of DNA from human tumors
Miguel A. Gama-Sosa,Valerie A. Slagel,Ronald W. Trewyn,Ronald Oxenhandler,Kenneth C. Kuo,Charles W. Gehrke,Melanie Ehrlich +6 more
TL;DR: Most of the metastatic neoplasms had significantly lower genomic m5C contents than did most of the benign neoplasm or normal tissues, which might reflect an involvement of extensive demethylation of DNA in tumor progression.
Journal ArticleDOI
Analysis of repetitive element DNA methylation by MethyLight
Daniel J. Weisenberger,Mihaela Campan,Tiffany I. Long,Myungjin Kim,Christian B. Woods,Emerich S. Fiala,Melanie Ehrlich,Peter W. Laird +7 more
TL;DR: This work reports the development of quantitative MethyLight assays to determine the levels of methylated and unmethylated repeats, namely, Alu and LINE-1 sequences and the centromeric satellite alpha (Satα) and juxtacentromeric satellites 2 (Sat2) DNA sequences.