G
Guangming Gan
Researcher at Southeast University
Publications - 4
Citations - 355
Guangming Gan is an academic researcher from Southeast University. The author has contributed to research in topics: Autophagy & Receptor tyrosine kinase. The author has an hindex of 3, co-authored 3 publications receiving 238 citations.
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Journal ArticleDOI
Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124–2HG
Rongrong Huang,Yuan Zhang,Bing Han,Ying Bai,Rongbin Zhou,Guangming Gan,Jie Chao,Gang Hu,Honghong Yao +8 more
TL;DR: It is shown that the circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 (MIR 124–2HG) sponge to sequester MIR124– 2HG and inhibit its activity, resulting in increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression.
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The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance
TL;DR: An HGF-MET axis-coordinated functional interaction between tyrosine kinase signaling and autophagy is established, and a MET-autophagy double-targeted strategy to overcome chemotherapeutic resistance in liver cancer is established.
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Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Yuan Zhang,Kai Shen,Ying-Ying Bai,Xuan Lv,Rongrong Huang,Wei Zhang,Jie Chao,Lan K. Nguyen,Jun Hua,Guangming Gan,Gang Hu,Honghong Yao +11 more
TL;DR: In vivo relevance was confirmed in mouse models, which demonstrated that the microinjection of anti-Mir143 into the hippocampus ameliorated the methamphetamine-induced decrease in microglia as well as that observed in heterozygous Mir143+/− mice.
Journal ArticleDOI
GTPase-activating Protein TBC1D5 coordinates with retromer to constrain synaptic growth by inhibiting BMP signaling.
Xiu Zhou,Guangming Gan,Yichen Sun,Mengzhu Ou,Jian Guo Geng,Jing Wang,Xi Yang,Shu-Hua Huang,Da Jia,Wei-dong Xie,Haihuai He +10 more
TL;DR: In this paper , the authors show that TBC1D5 is required for inhibition of synaptic growth, and loss of TBC 1D5 leads to abnormal presynaptic terminal development, including excessive satellite boutons and branch formation.