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Guangyan Zhangyuan
Researcher at Nanjing Medical University
Publications - 15
Citations - 415
Guangyan Zhangyuan is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Metastasis & Medicine. The author has an hindex of 8, co-authored 12 publications receiving 227 citations. Previous affiliations of Guangyan Zhangyuan include Nanjing University.
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Journal ArticleDOI
14-3-3ζ delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes.
Xiaochen Wang,Haiyuan Shen,Guangyan Zhangyuan,Ruyi Huang,Wenjie Zhang,Qifeng He,Kangpeng Jin,Han Zhuo,Zechuan Zhang,Jin-Cheng Wang,Beicheng Sun,Beicheng Sun,Xiao-Jie Lu +12 more
TL;DR: It is demonstrated for the first time that 14-3-3ζ expression was up-regulated in and inhibited the anti-tumor functions of tumor-infiltrating T cells in HCC microenvironment and that 14,3- 3ζ might be transmitted from HCC cells to T cells at least partially through exosomes.
Journal ArticleDOI
Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma.
Ruyi Huang,Xiaochen Wang,Wenjie Zhang,Guangyan Zhangyuan,Kangpeng Jin,Weiwei Yu,Yu Xie,Xiaoliang Xu,Hai Wang,Beicheng Sun +9 more
TL;DR: The results suggest that DGCR5 may be a participator in HCC and can serve as potential biomarker for the diagnosis and prognosis in H CC.
Journal ArticleDOI
VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR-PI3K-AKT pathway
Guangyan Zhangyuan,Fei Wang,Fei Wang,Haitian Zhang,Haitian Zhang,Runqiu Jiang,Runqiu Jiang,Xue-Wen Tao,Xue-Wen Tao,Decai Yu,Kangpeng Jin,Kangpeng Jin,Weiwei Yu,Yang Liu,Yang Liu,Yin Yin,Jintao Shen,Qinfeng Xu,Wenjie Zhang,Wenjie Zhang,Beicheng Sun,Beicheng Sun +21 more
TL;DR: Both in vitro and in vivo experiments show that knockdown of VersicanV1 in HCC cells attenuates cancer cells malignancy, suggesting that Versican V1 is an indicator for prognosis and a potential therapeutic target of HCC.
Journal ArticleDOI
CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein-Coupled Receptor-Mediated Signaling in Hepatocellular Carcinoma.
Yin Yin,Yin Yin,Xiaoliang Xu,Xiaoliang Xu,Junwei Tang,Junwei Tang,Wenjie Zhang,Wenjie Zhang,Guangyan Zhangyuan,Guangyan Zhangyuan,Jie Ji,Jie Ji,Lei Deng,Lei Deng,Shuai Lu,Han Zhuo,Beicheng Sun,Beicheng Sun +17 more
TL;DR: The utility of CD97 as an effective potential prognosticator and therapeutic target for HCC is supported and integrated regulatory interactions between CD97 and GRK6 stimulated downstream matrix metalloproteinase 2/9 secretion and, consequently, HCC metastasis.
Journal ArticleDOI
Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
Wenjie Zhang,Xiaochen Wang,Ruyi Huang,Kangpeng Jin,Guangyan Zhangyuan,Weiwei Yu,Yin Yin,Hai Wang,Zekuan Xu,Beicheng Sun +9 more
TL;DR: A stratified analysis showed that widowed patients always had the lowest CSS rate across different cancer stage, age and gender subgroups, and unmarried patients were at greater risk of cancer-specific mortality.