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Guangyao Lv
Researcher at Yantai University
Publications - 12
Citations - 194
Guangyao Lv is an academic researcher from Yantai University. The author has contributed to research in topics: Cancer & Internal medicine. The author has an hindex of 5, co-authored 7 publications receiving 153 citations.
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Journal ArticleDOI
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo.
Guangyao Lv,Dengjun Sun,Jingwen Zhang,Xiaoxia Xie,Xiaoqiong Wu,Wei-Shuo Fang,Jingwei Tian,Chunhong Yan,Hongbo Wang,Fenghua Fu +9 more
TL;DR: The potential of Lx2-32c as a candidate antitumor agent for the treatment of prostate cancer is demonstrated, with results equivalent to those of docetaxel.
Journal ArticleDOI
Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer
Mingmin Ding,Hongbo Wang,Chunrong Qu,Fuchun Xu,Yingmin Zhu,Guangyao Lv,Yungang Lu,Qingjun Zhou,Hui Zhou,Xiaodong Zeng,Jingwen Zhang,Chunhong Yan,Jiacheng Lin,Huai-Rong Luo,Zixing Deng,Yuling Xiao,Jinbin Tian,Michael X. Zhu,Xuechuan Hong,Xuechuan Hong +19 more
TL;DR: A new tool compound is found which shows excellent therapeutic potential against human gastric cancer most likely through targeting TRPC6 channels.
Journal ArticleDOI
Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives.
Yi Bi,Xiao Yang,Zhang Tingting,Ze-Yun Liu,Xiaochen Zhang,Jing Lu,Keguang Cheng,Jinyi Xu,Hongbo Wang,Guangyao Lv,Peter J. Lewis,Qing-Guo Meng,Cong Ma +12 more
TL;DR: The results demonstrate that nitrated substitutions at C-3 of ocotillol-type derivatives could provide an approach to expand their antibacterial spectrum, and that ocotilla-type triterpenoids may also be developed as appropriate carriers for NO donors in antibacterial agent discovery with low cytotoxicity.
Journal ArticleDOI
The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo
Hongbo Wang,Liang Kong,Jianqiao Zhang,Guohua Yu,Guangyao Lv,Fangxi Zhang,Xiaoguang Chen,Jingwei Tian,Fenghua Fu +8 more
TL;DR: Pseudoginsenoside F11 enhanced rather than inhibited the anti-tumor activity of cispaltin in murine melanoma and Lewis lung cancer xenograft tumor models, suggesting that administering F11 with cisplatin might alleviate the associated nephrotoxicity without compromising its therapeutic efficiency.
Journal ArticleDOI
Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation.
Jianqiao Zhang,Leiming Zhang,Xue Sun,Yanting Yang,Liang Kong,Chengwen Lu,Guangyao Lv,Tian Wang,Hongbo Wang,Fenghua Fu +9 more
TL;DR: It is demonstrated that the tested AChEIs, excluding neostigmine, could attenuate APAP-induced liver injury, accompanied by reduced reactive oxygen species formation, adenosine triphosphate and cytochrome C loss, c-Jun N-terminal kinase 2 (JNK2) phosphorylation, and cytokines.