Guanxiang Qian

TL;DR: Using primary rat and human neuronal cultures, it is confirmed that interleukin‐1β and tumor necrosis factor‐α, two pro‐inflammatory cytokines that are typically elevated in neurodegenerative disease states, induced neuronal death and apoptosis in vitro.

TL;DR: Tumor suppressor microRNA miR‐145 is commonly down‐regulated in colon carcinoma tissues, but its specific role in tumors remains unknown.

TL;DR: A long noncoding RNA directly builds an intrachromosomal interaction complex to establish allele-specific transcriptional gene silencing over a large chromosomal domain.

TL;DR: It is shown that the lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation, which significantly reduces tumor growth and metastasis.

TL;DR: Cloned and identified the proximal 269 bp promoter of survivin gene, which exhibited strong promoter activity in HeLa cells, and suggests that Sp1 cooperates with Sp3 to regulate survivin promoter activity.