G
Gudrun Antoons
Researcher at Maastricht University
Publications - 57
Citations - 1963
Gudrun Antoons is an academic researcher from Maastricht University. The author has contributed to research in topics: Afterdepolarization & Ryanodine receptor. The author has an hindex of 26, co-authored 57 publications receiving 1766 citations. Previous affiliations of Gudrun Antoons include University of Michigan & Catholic University of Leuven.
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Journal ArticleDOI
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation.
Nan Wang,Marijke De Bock,Gudrun Antoons,Ashish K. Gadicherla,Mélissa Bol,Elke Decrock,William Howard Evans,Karin R. Sipido,Feliksas F. Bukauskas,Luc Leybaert +9 more
TL;DR: Results indicate that under pathological conditions, when [Ca2+]i is elevated, Cx43 HC opening is promoted in cardiomyocytes and CxMPs counteract this effect.
Journal ArticleDOI
Mechanisms underlying the frequency dependence of contraction and [Ca2+]i transients in mouse ventricular myocytes
TL;DR: In mouse ventricular myocytes the [Ca2+]i‐frequency response depends on a balance between the increase in SR content and the loss of trigger ICa,L, and small changes in this balance may contribute to variability in frequency‐dependent behaviour.
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Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Mark Ver Heyen,Stephane Heymans,Gudrun Antoons,Thomas D. Reed,Muthu Periasamy,Bonaventure Awede,Jean Lebacq,Peter Vangheluwe,Mieke Dewerchin,Desire Collen,Karin R. Sipido,Peter Carmeliet,Frank Wuytack +12 more
TL;DR: Comparison of data obtained with those obtained in mice expressing similar cardiac levels of SERCA2a instead ofSERCA2b indicate the importance of the muscle-specific SERCA 2a isoform for normal cardiac development and for the cardiac contraction-relaxation cycle.
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Spatial and Temporal Inhomogeneities During Ca2+ Release From the Sarcoplasmic Reticulum in Pig Ventricular Myocytes
Frank R. Heinzel,Virginie Bito,Paul G.A. Volders,Gudrun Antoons,Kanigula Mubagwa,Karin R. Sipido +5 more
TL;DR: In pig ventricular myocytes, areas of delayed release are related to regional absence of T tubules but not ryanodine receptors, which contributes to a slower overall rate of rise of [Ca2+]i.
Journal ArticleDOI
Late Na Current Inhibition by Ranolazine Reduces Torsades de Pointes in the Chronic Atrioventricular Block Dog Model
Gudrun Antoons,Avram Oros,Jet D.M. Beekman,Markus A. Engelen,Marien J C Houtman,Luiz Belardinelli,Milan Stengl,Milan Stengl,Marc A. Vos +8 more
TL;DR: Despite down-regulation of I(NaL) in remodeled cAVB hearts, ranolazine is antiarrhythmic against drug-induced TdP, which is reflected in concomitant changes of BVR.