L
Luc Leybaert
Researcher at Ghent University
Publications - 216
Citations - 12209
Luc Leybaert is an academic researcher from Ghent University. The author has contributed to research in topics: Connexin & Gap junction. The author has an hindex of 59, co-authored 207 publications receiving 10672 citations. Previous affiliations of Luc Leybaert include Ghent University Hospital & University of Massachusetts Amherst.
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Journal ArticleDOI
Engaging neuroscience to advance translational research in brain barrier biology
Edward A. Neuwelt,Björn Bauer,Christoph Fahlke,Gert Fricker,Constantino Iadecola,Damir Janigro,Luc Leybaert,Zoltán Molnár,Martha E O'Donnell,John T. Povlishock,Norman R. Saunders,Frank R. Sharp,Danica Stanimirovic,Ryan J. Watts,Lester R. Drewes +14 more
TL;DR: The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood–brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier.
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The gap junction cellular internet: connexin hemichannels enter the signalling limelight.
TL;DR: Cxs (connexins), the protein subunits forming gap junction intercellular communication channels, are transported to the plasma membrane after oligomerizing into hexameric assemblies called connexin hemichannels (CxHcs), suggesting a prominent role in cellular Ca2+ homoeostasis and signalling.
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Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.
Tania Løve Aaes,Agnieszka Kaczmarek,Tinneke Delvaeye,Bram De Craene,Stefaan De Koker,Liesbeth Heyndrickx,Iris Delrue,Joachim Taminau,Bartosz Wiernicki,Philippe De Groote,Abhishek D. Garg,Luc Leybaert,Johan Grooten,Mathieu J.M. Bertrand,Patrizia Agostinis,Geert Berx,Wim Declercq,Peter Vandenabeele,Dmitri V. Krysko +18 more
TL;DR: A genetic model in which direct dimerization of FADD combined with inducible expression of RIPK3 promotes necroptosis is developed, which broadens the current concept of immunogenic cell death and opens doors for the development of new strategies in cancer therapy.
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Intracellular calcium changes trigger connexin 32 hemichannel opening
Elke De Vuyst,Elke Decrock,Liesbet Cabooter,George R. Dubyak,Christian C. Naus,W. Howard Evans,Luc Leybaert +6 more
TL;DR: The hypothesis that an increase of cytoplasmic calcium concentration ([Ca2+]i) triggers hemichannel opening is investigated, and results suggest that these channels are under physiological control.
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Intercellular Ca2+ Waves: Mechanisms and Function
TL;DR: The mechanisms of initiation and propagation of ICWs, the key intra- and extracellular messengers (inositol 1,4,5-trisphosphate and ATP) mediating ICW, and the proposed physiological functions of ICW are reviewed.