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Gui Jie Feng
Researcher at Cardiff University
Publications - 21
Citations - 2816
Gui Jie Feng is an academic researcher from Cardiff University. The author has contributed to research in topics: G protein & Immune system. The author has an hindex of 15, co-authored 20 publications receiving 2743 citations. Previous affiliations of Gui Jie Feng include University of Surrey & University of Glasgow.
Papers
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Journal ArticleDOI
Altered immune responses in mice lacking inducible nitric oxide synthase
Xiao-Qing Wei,I. G. Charles,Austin Smith,Jan Ure,Gui Jie Feng,Fang-Ping Huang,Damo Xu,Werner Müller,Salvador Moncada,Foo Y. Liew +9 more
TL;DR: The infected mutant mice developed a significantly stronger Thl type of immune response than the wild-type or heterozygous mice, and showed reduced nonspecific inflammatory response to carrageenin, and were resistant to lipopolysaccharide-induced mortality.
Journal Article
Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
Gui Jie Feng,Helen S. Goodridge,Margaret M. Harnett,Xiao-Qing Wei,Andrei V. Nikolaev,Adrian P. Higson,Foo Y. Liew +6 more
TL;DR: As ERK and p38 MAP kinases differentially regulate the induction of the macrophage effector molecules, inducible NO synthase and IL-12, these kinases are potential targets not only for the development of novel strategies to combat intracellular pathogens but also for therapeutic immunomodulation.
Journal ArticleDOI
Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages
Fang-Ping Huang,Wanda Niedbala,Xiao-Qing Wei,Damo Xu,Gui Jie Feng,John H. Robinson,Charles Lam,Fooyew Liew +7 more
TL;DR: The data demonstrate that NO can be an inhibitor of this feedback loop, preventing the excessive amplification of Th1 cells which are implicated in a range of immunopathologies.
Journal ArticleDOI
Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages
Lorna Proudfoot,Andrei V. Nikolaev,Gui Jie Feng,Xiao-Qing Wei,Michael A. J. Ferguson,John S. Brimacombe,Foo Y. Liew +6 more
TL;DR: It is demonstrated that LPG glycoconjugates have a profound effect on the survival of Leishmania parasites through their ability to regulate the expression of iNOS by macrophages.
Journal Article
Altered Immune Responses and Susceptibility to Leishmania major and Staphylococcus aureus Infection in IL-18-Deficient Mice
Xiao-Qing Wei,Bernard P. Leung,Wanda Niedbala,David Piedrafita,Gui Jie Feng,Matthew J. Sweet,Lorraine Dobbie,Andrew J.H. Smith,Foo Y. Liew +8 more
TL;DR: Results provide direct evidence that IL-18 is not only essential for the host defense against intracellular infection, but it also plays a critical role in regulating the synthesis of inflammatory cytokines, and therefore could be an important target for therapeutic intervention.