Jan Ure

TL;DR: The infected mutant mice developed a significantly stronger Thl type of immune response than the wild-type or heterozygous mice, and showed reduced nonspecific inflammatory response to carrageenin, and were resistant to lipopolysaccharide-induced mortality.

TL;DR: Data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects, and show that TTX-resistant sodium channel α subunit is encoded by the sns gene.

TL;DR: Three different HLA-A2.1 monochains were engineered in which either the human or mouse β2-microglobulin (β2m) is covalently linked to the NH2 terminus of the heavy chain by a 15– amino acid long peptide, and the selected HHD construct was introduced by transgenesis in H-2Db/− β2m−/− double knockout mice.

TL;DR: The phenotype of derived mice that carry a targeted nonsense mutation in the endoglin gene is remarkably similar to that of the T GFbeta1 and the TGFbeta receptor II knockout mice, indicating that endogslin is needed in vivo for TGF beta1 signaling during extraembryonic vascular development.

TL;DR: The estimates indicate that the cumulative activity of the AGM region and the yolk sac is sufficient to provide the day 12 liver with a large number of definitive HSC/RUs, suggesting that the large pool of Definitive HSCs in day 12 foetal liver is formed predominantly by recruiting 'ready-to-use' definitive H SCs from extra-hepatic sources.