M
Matthew J. Sweet
Researcher at University of Queensland
Publications - 181
Citations - 14507
Matthew J. Sweet is an academic researcher from University of Queensland. The author has contributed to research in topics: Innate immune system & Proinflammatory cytokine. The author has an hindex of 58, co-authored 166 publications receiving 12596 citations. Previous affiliations of Matthew J. Sweet include University of Glasgow & Cooperative Research Centre.
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Journal ArticleDOI
Endotoxin signal transduction in macrophages
Matthew J. Sweet,David A. Hume +1 more
TL;DR: The effects of LPS on macrophages are examined by following events from the cell surface to the nucleus and the involvement of protein tyrosine kinase, mitogen‐activated protein kinases, protein kinase C, G proteins, Protein kinase A, ceramide‐activatedprotein kinase and microtubules in this process are reviewed.
Journal ArticleDOI
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.
Tara L. Roberts,Adi Idris,Jasmyn A. Dunn,Greg Kelly,Carol M. Burnton,Samantha Hodgson,Lani Hardy,Valerie Garceau,Matthew J. Sweet,Ian L. Ross,David A. Hume,Katryn J. Stacey +11 more
TL;DR: This work identifies the HIN-200 family member and candidate lupus susceptibility factor, p202, as a dsDNA binding protein that bound stably and rapidly to transfected DNA and indicates that Hin-200 proteins can act as pattern recognition receptors mediating responses to cytoplasmic ds DNA.
Journal Article
Macrophages ingest and are activated by bacterial DNA.
TL;DR: Results suggest that DNA is taken up by macrophages and characteristic bacterial DNA sequences, which include an unmethylated CpG sequence, activate a signaling cascade leading to activation of NF-kappa B and inflammatory gene induction.
Journal ArticleDOI
LPS-induced cytokine production in human monocytes and macrophages.
Manuela Rossol,Holger Heine,Undine Meusch,Dagmar Quandt,Carina Klein,Matthew J. Sweet,Sunna Hauschildt +6 more
TL;DR: An overview of LPS signal transduction is provided with attention given to receptor cooperativity and species differences in LPS responses, as well as the role of tyrosine phosphorylation and lysine acetylation in signalling.
Journal ArticleDOI
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
Harukazu Suzuki,Alistair R. R. Forrest,Erik van Nimwegen,Carsten O. Daub,Piotr J. Balwierz,Katharine M. Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J. L. de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy L. Bailey,Vladimir B. Bajic,Denis C. Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M. Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josée Dostie,Pär G. Engström,Magbubah Essack,Geoffrey J. Faulkner,J. Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M. Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Winston Hide,Oliver Hofmann,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C. Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Ross MacPherson,Norihiro Maeda,Christopher G. Maher,Monique Maqungo,Jessica C. Mar,Nicholas Matigian,Hideo Matsuda,John S. Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S. Schwartz,Colin A. Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,Georges St. Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J. Sweet,Ryan J. Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S. Taylor,Rohan D. Teasdale,Jesper Tegnér,Jesper Tegnér,Sarah A. Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A. Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A. Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki +162 more
TL;DR: The results indicate that cellular states are constrained by complex networks involving both positive and negative regulatory interactions among substantial numbers of transcription factors and that no single transcription factor is both necessary and sufficient to drive the differentiation process.