Guibin Li

TL;DR: It is demonstrated that exposing muscle cells to particular saturated free fatty acids, but not mono-unsaturated FFAs, inhibits insulin stimulation of Akt/protein kinase B, a serine/threonine kinase that is a central mediator of insulin-stimulated anabolic metabolism.

TL;DR: It is reported that paclitaxel (taxol) prevents cell death induced by Aβ peptides, inhibits Aβ‐induced activation of cyclin‐dependent kinase 5 (cdk5) and decreases tau hyperphosphorylation.

TL;DR: The results suggest that drugs that interact with MTs can alter signaling events in neurons, possibly because some MTs play a role in organizing protein complexes involved in responses to Aβ.

TL;DR: Ceramide inhibited Aß-induced calpain activation and cdk5 activity in wild-type neurons and protected against neuronal death and tau hyperphosphorylation, suggesting that ceramide can regulate Aß cell toxicity in a p35/cdk5-dependent manner.

TL;DR: The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel as discussed by the authors , which support the systematic analysis of the medical literature from peer reviewed journals.