J
Jose Antonio Chavez
Researcher at Duke University
Publications - 9
Citations - 2355
Jose Antonio Chavez is an academic researcher from Duke University. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 8, co-authored 9 publications receiving 2188 citations. Previous affiliations of Jose Antonio Chavez include University of Utah & Colorado State University.
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Journal ArticleDOI
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.
Jose Antonio Chavez,Trina A. Knotts,Liping Wang,Guibin Li,Rick T. Dobrowsky,Gregory L. Florant,Scott A. Summers +6 more
TL;DR: It is demonstrated that exposing muscle cells to particular saturated free fatty acids, but not mono-unsaturated FFAs, inhibits insulin stimulation of Akt/protein kinase B, a serine/threonine kinase that is a central mediator of insulin-stimulated anabolic metabolism.
Journal ArticleDOI
A Ceramide-Centric View of Insulin Resistance
TL;DR: This review discusses from a historical perspective the most important discoveries produced over the last decade supporting a role for ceramide and its metabolites in the pathogenesis of insulin resistance and other obesity-associated metabolic diseases.
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Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes.
TL;DR: Findings implicate excess delivery of long-chain fatty acids in the development of insulin resistance resulting from lipid oversupply to skeletal muscle and using myotubes implicate free fatty acids capable of inhibiting insulin action.
Journal ArticleDOI
Lipid mediators of insulin resistance.
William L. Holland,Trina A. Knotts,Jose Antonio Chavez,Liping Wang,Kyle L. Hoehn,Scott A. Summers +5 more
TL;DR: The metabolic fates of lipids in insulin-responsive tissues are reviewed and the roles of specific lipid metabolites (e.g., ceramides, GM3 ganglioside, and diacylglycerol) as antagonists of insulin signaling and action are discussed.
Journal ArticleDOI
Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling
TL;DR: A role for aberrant accumulation of ceramide, but not sphingosine, in the inhibition of muscle insulin sensitivity by exogenous FFAs is supported, as well as the contribution of either sphingolipid in FFA-dependent inhibition of insulin action.