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Scott A. Summers
Researcher at University of Utah
Publications - 135
Citations - 15718
Scott A. Summers is an academic researcher from University of Utah. The author has contributed to research in topics: Ceramide & Insulin resistance. The author has an hindex of 48, co-authored 116 publications receiving 13516 citations. Previous affiliations of Scott A. Summers include Southern Illinois University Carbondale & Colorado State University.
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Journal ArticleDOI
Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
TL;DR: It is shown that Akt can regulate glucose uptake and metabolism and is expressed in 3T3-L1 adipocytes directed lipid but not glycogen synthesis.
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Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance
William L. Holland,Joseph T. Brozinick,Liping Wang,Eric D. Hawkins,Katherine M. Sargent,Yanqi Liu,Krishna K. Narra,Kyle L. Hoehn,Trina A. Knotts,Angela M. Siesky,Don H. Nelson,Sotirios K. Karathanasis,Greg K Fontenot,Morris J. Birnbaum,Scott A. Summers +14 more
TL;DR: It is demonstrated that the sphingolipid ceramide is a common molecular intermediate linking several different pathological metabolic stresses to the induction of insulin resistance, and enzymes required for ceramide synthesis are identified as therapeutic targets for combating insulin resistance caused by nutrient excess or glucocorticoid therapy.
Journal ArticleDOI
Ceramides in insulin resistance and lipotoxicity.
TL;DR: The contribution of ceramides in the development of insulin resistance and the complications associated with metabolic diseases is evaluated.
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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
William L. Holland,Russell A. Miller,Zhao V. Wang,Kai Sun,Brian M. Barth,Hai H. Bui,Kathryn Davis,Benjamin T. Bikman,Nils Halberg,Nils Halberg,Joseph M. Rutkowski,Mark R. Wade,Vincent M. Tenorio,Ming Shang Kuo,Joseph T. Brozinick,Bei B. Zhang,Morris J. Birnbaum,Scott A. Summers,Scott A. Summers,Scott A. Summers,Philipp E. Scherer +20 more
TL;DR: Observations suggest a unifying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolipid metabolism as its core upstream signaling component.
Journal ArticleDOI
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
William L. Holland,Benjamin T. Bikman,Liping Wang,Guan Yuguang,Katherine M. Sargent,Sarada Bulchand,Trina A. Knotts,Guanghou Shui,Deborah J. Clegg,Markus R. Wenk,Michael J. Pagliassotti,Philipp E. Scherer,Scott A. Summers,Scott A. Summers,Scott A. Summers +14 more
TL;DR: It is shown here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis, and that sphingolipids such as ceramide might be key components of the signaling networks that link lipid-induced inflammatory pathways to the antagonism of insulin action that contributes to diabetes.