Guido Merlotti

TL;DR: In conclusion, EVs sustain an intricate crosstalk between graft tissue and innate/adaptive immune systems and are promising as biomarkers and therapeutic tools in KT.

TL;DR: A causal link between viral infections and autoimmunity has been studied for a long time and the role of some viruses in the induction or exacerbation of systemic lupus erythematosus (SLE) in genetically predisposed patients has been proved as discussed by the authors.

TL;DR: New biomarkers of early and late graft dysfunction are needed in renal transplant to improve management of complications and prolong graft survival, and introduction of these new sets of biomarkers into clinical practice could actually reduce the need for renal biopsy, integrate traditional tools, and ultimately improve graft survival compared to current management.

TL;DR: FHH should be clearly differentiated by PHPT to avoid unnecessary surgery: CCCR could be a useful screening tool while genetic analysis should include the two novel CaSR mutations herein described.

TL;DR: In renal transplant patients, TCF7L2 rs7903146 is strongly and independently associated with PTDM and might hold the potential to identify patients at risk for this complication.