G
Guilherme De Sena Brandine
Researcher at University of Southern California
Publications - 15
Citations - 620
Guilherme De Sena Brandine is an academic researcher from University of Southern California. The author has contributed to research in topics: Kidney development & DNA methylation. The author has an hindex of 7, co-authored 12 publications receiving 328 citations. Previous affiliations of Guilherme De Sena Brandine include Federal University of Ceará & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.
Nils O. Lindström,Jinjin Guo,Albert D. Kim,Tracy S. Tran,Qiuyu Guo,Guilherme De Sena Brandine,Andrew Ransick,Riana K. Parvez,Matthew E. Thornton,Laurence Basking,Brendan H. Grubbs,Jill A. McMahon,Andrew D. Smith,Andrew P. McMahon +13 more
TL;DR: This study provides a benchmark for the mesenchymal progenitors in the human nephrogenic niche and highlights species-variability in kidney developmental programs.
Journal ArticleDOI
Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis
Nils O. Lindström,Guilherme De Sena Brandine,Tracy S. Tran,Andrew Ransick,Gio C. Suh,Jinjin Guo,Albert D. Kim,Riana K. Parvez,Seth Ruffins,Elisabeth A. Rutledge,Matthew E. Thornton,Brendan H. Grubbs,Jill A. McMahon,Andrew D. Smith,Andrew P. McMahon +14 more
TL;DR: Evidence is presented that human nephrons patterning reflects a time-dependent process of recruitment of mesenchymal progenitors into an epithelial nephron precursor, which provides a framework for integrating signaling pathways driving mammalian nephrogenesis.
Journal ArticleDOI
Falco: high-speed FastQC emulation for quality control of sequencing data.
TL;DR: Falco as mentioned in this paper is an emulation of the FastQC tool that runs on average three times faster while generating equivalent results, and it also requires less memory to run and provides more flexible visualization of HTML reports.
Journal ArticleDOI
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes
Tracy S. Tran,Nils O. Lindström,Andrew Ransick,Guilherme De Sena Brandine,Qiuyu Guo,Albert D. Kim,Balint Der,Janos Peti-Peterdi,Andrew D. Smith,Matthew E. Thornton,Brendan H. Grubbs,Jill A. McMahon,Andrew P. McMahon +12 more
TL;DR: Human podocyte development is mostly intrinsically regulated and vascular interactions refine maturation, and the application of organoid-derived podocytes to model disease and to restore or replace normal kidney functions is supported.
Posted ContentDOI
Spatial Transcriptional Mapping of the Human Nephrogenic Program
Nils O. Lindström,Rachel Sealfon,Xi Chen,Riana K. Parvez,Andrew Ransick,Guilherme De Sena Brandine,Jinjin Guo,Bill Hill,Tracy S. Tran,Albert D. Kim,Jian Zhou,Alicja Tadych,Aaron Watters,Aaron B. Wong,Elizabeth Lovero,Brendan H. Grubbs,Matthew E. Thornton,Jill A. McMahon,Andrew D. Smith,Seth Ruffins,Chris Armit,Olga G. Troyanskaya,Andrew P. McMahon +22 more
TL;DR: The spatially resolved nephrogenic program made available through the Human Nephrogenesis Atlas will facilitate an understanding of kidney development and disease, and enhance efforts to generate new kidney structures.