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Qiuyu Guo
Researcher at University of Southern California
Publications - 15
Citations - 591
Qiuyu Guo is an academic researcher from University of Southern California. The author has contributed to research in topics: Enhancer & Medicine. The author has an hindex of 5, co-authored 7 publications receiving 365 citations.
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Journal ArticleDOI
Conserved and Divergent Features of Human and Mouse Kidney Organogenesis
Nils O. Lindström,Jill A. McMahon,Jinjin Guo,Tracy S. Tran,Qiuyu Guo,Elisabeth A. Rutledge,Riana K. Parvez,Gohar Saribekyan,Robert Schuler,Christopher D. Liao,Albert D. Kim,Ahmed Abdelhalim,Seth Ruffins,Matthew E. Thornton,Laurence Basking,Brendan H. Grubbs,Carl Kesselman,Andrew P. McMahon +17 more
TL;DR: The data will facilitate and inform in vitro efforts to generate human kidney structures and comparative functional analyses across mammalian species and highlight differences in molecular and cellular features, including the expression and cellular distribution of anchor gene markers used to identify key cell types in mouse kidney studies.
Journal ArticleDOI
Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney.
Nils O. Lindström,Jinjin Guo,Albert D. Kim,Tracy S. Tran,Qiuyu Guo,Guilherme De Sena Brandine,Andrew Ransick,Riana K. Parvez,Matthew E. Thornton,Laurence Basking,Brendan H. Grubbs,Jill A. McMahon,Andrew D. Smith,Andrew P. McMahon +13 more
TL;DR: This study provides a benchmark for the mesenchymal progenitors in the human nephrogenic niche and highlights species-variability in kidney developmental programs.
Journal ArticleDOI
Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.
Lori L. O'Brien,Qiuyu Guo,Young-Jin Lee,Tracy S. Tran,Jean-Denis Benazet,Peter H. Whitney,Anton Valouev,Andrew P. McMahon +7 more
TL;DR: A comparison of Six2/SIX2 regulatory targets in mouse and human nephron progenitors reveals that Six1/Six1 is differentially regulated and expressed between the two species.
Journal ArticleDOI
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes
Tracy S. Tran,Nils O. Lindström,Andrew Ransick,Guilherme De Sena Brandine,Qiuyu Guo,Albert D. Kim,Balint Der,Janos Peti-Peterdi,Andrew D. Smith,Matthew E. Thornton,Brendan H. Grubbs,Jill A. McMahon,Andrew P. McMahon +12 more
TL;DR: Human podocyte development is mostly intrinsically regulated and vascular interactions refine maturation, and the application of organoid-derived podocytes to model disease and to restore or replace normal kidney functions is supported.
Journal ArticleDOI
Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.
Lori L. O'Brien,Qiuyu Guo,Emad Bahrami-Samani,Joo-Seop Park,Sean M. Hasso,Young-Jin Lee,Alan Fang,Albert D. Kim,Jinjin Guo,Trudy Hong,Kevin A. Peterson,Scott Lozanoff,Ramya Raviram,Bing Ren,Ben Fogelgren,Andrew D. Smith,Anton Valouev,Andrew P. McMahon +17 more
TL;DR: The view of the regulatory genome and regulatory landscape underpinning mammalian nephrogenesis is expanded and an inversion of the Six2/Six3 locus around the CTCF-bound boundary is identified, removing Six2 from its distal enhancer regulation, but placed next to Six3 enhancer elements which support ectopic Six2 expression in the lens where Six3 is normally expressed.