G
Guillermo Díaz-Araya
Researcher at University of Chile
Publications - 91
Citations - 13233
Guillermo Díaz-Araya is an academic researcher from University of Chile. The author has contributed to research in topics: Receptor & Heart failure. The author has an hindex of 31, co-authored 84 publications receiving 10695 citations. Previous affiliations of Guillermo Díaz-Araya include Pontifical Catholic University of Chile & Valparaiso University.
Papers
More filters
Journal ArticleDOI
Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
Pablo Aránguiz-Urroz,Jimena Canales,Miguel Copaja,Rodrigo Troncoso,Jose Miguel Vicencio,Constanza Carrillo,Hernan E. Lara,Sergio Lavandero,Guillermo Díaz-Araya +8 more
TL;DR: It is suggested that b(2)-adrenergic stimulation triggers autophagy in cardiac fibroblasts, and that this response could contribute to reduce the deleterious effects of high adrenergic stimulation upon cardiac fibrosis.
Journal ArticleDOI
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol.
Pedro Ayala,J. Montenegro,Raúl Vivar,Alan Letelier,Pablo Daniel Aránguiz Urroz,Miguel Copaja,Deisy Pivet,Claudio Humeres,Rodrigo Troncoso,Jose Miguel Vicencio,Sergio Lavandero,Guillermo Díaz-Araya +11 more
TL;DR: The results suggest that cardiac damage and fibrosis induced in vivo by the beta-adrenergic agonist ISO are tightly related to ER stress signaling pathways, and that increasing the ER luminal folding capacity with exogenously administrated 4-PBA is a powerful strategy for preventing the development of cardiac fibrosis.
Journal ArticleDOI
Fibroblast Primary Cilia Are Required for Cardiac Fibrosis.
Elisa Villalobos,Elisa Villalobos,Alfredo Criollo,Alfredo Criollo,Gabriele G. Schiattarella,Francisco Altamirano,Kristin M. French,Herman I. May,Nan Jiang,Ngoc Uyen Nhi Nguyen,Diego Romero,Juan Carlos Roa,Lorena García,Guillermo Díaz-Araya,Eugenia Morselli,Anwarul Ferdous,Simon J. Conway,Hesham A. Sadek,Thomas G. Gillette,Sergio Lavandero,Sergio Lavandero,Joseph A. Hill +21 more
TL;DR: Findings point to a pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling and suggest that some of the cardiovascular manifestations of autosomal dominant polycystic kidney disease derive directly from myocardium-autonomous abnormalities.
Journal ArticleDOI
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart.
Mauricio Ibacache,Gina Sánchez,Zully Pedrozo,Felipe Galvez,Claudio Humeres,Ghislaine C. Echevarria,Juan Duaso,Mario Hassi,Lorena García,Guillermo Díaz-Araya,Sergio Lavandero,Sergio Lavandero +11 more
TL;DR: Results show that dexmedetomidine preconditioning and dexmedeployomidine peri-insult administration produce cardioprotection against regional ischemia/reperfusion injury, which is mediated by the activation of pro-survival kinases after cardiac α(2)-adrenergic receptor stimulation.
Journal ArticleDOI
Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
María Paz Ocaranza,Jackeline Moya,Victor Barrientos,Rodrigo Alzamora,Daniel Hevia,Cristobal Morales,Melissa Pinto,Nicolás Escudero,Lorena García,Ulises Novoa,Pedro Ayala,Guillermo Díaz-Araya,Iván Godoy,Mario Chiong,Sergio Lavandero,Jorge E. Jalil,Luis Michea +16 more
TL;DR: Angiotensin-(1–9) reduces hypertension, ameliorates structural alterations (hypertrophy and fibrosis), oxidative stress in the heart and aorta and improves cardiac and endothelial function in hypertensive rats.