G
Guillermo Díaz-Araya
Researcher at University of Chile
Publications - 91
Citations - 13233
Guillermo Díaz-Araya is an academic researcher from University of Chile. The author has contributed to research in topics: Receptor & Heart failure. The author has an hindex of 31, co-authored 84 publications receiving 10695 citations. Previous affiliations of Guillermo Díaz-Araya include Pontifical Catholic University of Chile & Valparaiso University.
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Journal ArticleDOI
Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
Hernán Alcaíno,Douglas Greig,Mario Chiong,Hugo Verdejo,Rodrigo Miranda,Roberto Concepción,José Luis Vukasovic,Guillermo Díaz-Araya,Rosemarie Mellado,Lorena García,Daniela Salas,Leticia González,Iván Godoy,Pablo Castro,Sergio Lavandero +14 more
TL;DR: A positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure patients is suggested.
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Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation.
Pía Boza,Pedro Ayala,Raúl Vivar,Claudio Humeres,Felipe Tapia Cáceres,Claudia Muñoz,Lorena García,Marcela A. Hermoso,Guillermo Díaz-Araya +8 more
TL;DR: TGF-β1 increased TLR4 expression in CF and the process was mediated by the TGFβRI and p38 signaling pathways, and in both CF and CMF, LPS triggered ERK1/2, PI3K-Akt, and p65-NF-κB phosphorylation and the unsecreted pro-IL-1β in the CF was degraded by autophagy.
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IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB.
Carola Maldonado,Paola Cea,Tatiana Adasme,Andres Collao,Guillermo Díaz-Araya,Mario Chiong,Sergio Lavandero +6 more
TL;DR: It is suggested that IGF-1 activates CREB through a complex signalling pathway, and this transcription factor plays an important role in the anti-apoptotic action of IGF- 1 in cultured cardiac myocytes.
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Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Verónica Eisner,Alfredo Criollo,Clara Quiroga,Claudio Olea-Azar,Juan F. Santibanez,Rodrigo Troncoso,Mario Chiong,Guillermo Díaz-Araya,Rocio Foncea,Sergio Lavandero +9 more
TL;DR: The results showed that hyperosmotic stress generated ROS in cultured cardiac myocytes, in particular the hydroxyl and superoxide species, which were inhibited by N‐acetylcysteine (NAC).
Journal ArticleDOI
Oxidative stress after reperfusion with primary coronary angioplasty: lack of effect of glucose-insulin-potassium infusion.
Guillermo Díaz-Araya,Danniels Nettle,Pablo Castro,Fernando P. Miranda,Douglas Greig,Ximena Campos,Mario Chiong,Carolina Nazzal,Ramón Corbalán,Sergio Lavandero +9 more
TL;DR: Patients with acute myocardial infarction had increased levels of oxidative stress associated with a reduction in enzymatic antioxidant reserve and Administration of GIK solution did not improve these abnormalities among patients undergoing primary angioplasty.