G
Gunnar Drewes
Researcher at University of Potsdam
Publications - 4
Citations - 394
Gunnar Drewes is an academic researcher from University of Potsdam. The author has contributed to research in topics: Frataxin & Phosphorylation. The author has an hindex of 4, co-authored 4 publications receiving 374 citations.
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Journal ArticleDOI
Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.
Tim J. Schulz,René Thierbach,Anja Voigt,Gunnar Drewes,Brun H. Mietzner,Pablo Steinberg,Andreas Pfeiffer,Michael Ristow,Michael Ristow +8 more
TL;DR: The view that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals is supported.
Journal ArticleDOI
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
René Thierbach,Tim J. Schulz,Frank Isken,Aanja Voigt,Brun H. Mietzner,Gunnar Drewes,Jürgen-Christoph von Kleist-Retzow,Rudolf J. Wiesner,Mark A. Magnuson,Hélène Puccio,Andreas Pfeiffer,Pablo Steinberg,Michael Ristow +12 more
TL;DR: Findings indicate that frataxin may act as a mitochondrial tumor suppressor protein in mammals by promoting both apoptosis and proliferation in murine hepatocytes.
Journal ArticleDOI
The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals.
René Thierbach,René Thierbach,Gunnar Drewes,Markus Fusser,Anja Voigt,Doreen Kuhlow,Urte Blume,Urte Blume,Tim J. Schulz,Carina Reiche,Hansruedi Glatt,Bernd Epe,Pablo Steinberg,Pablo Steinberg,Michael Ristow +14 more
TL;DR: These findings indicate that frataxin modulates DNA-repair mechanisms probably due to its impact on ISC-dependent repair proteins, linking mitochondrial dysfunction to DNA repair and tumour initiation.
Journal ArticleDOI
Specific Alterations of Carbohydrate Metabolism Are Associated With Hepatocarcinogenesis in Mitochondrially Impaired Mice
René Thierbach,Simone Florian,Katharina Wolfrum,Anja Voigt,Gunnar Drewes,Urte Blume,Peter Bannasch,Michael Ristow,Pablo Steinberg +8 more
TL;DR: The hepatocarcinogenic process in AlbFxn(-/-) mice shows remarkable differences regarding carbohydrate metabolism alterations when compared with all other chemically and virally driven liver cancer models described up to now.