R
René Thierbach
Researcher at University of Jena
Publications - 22
Citations - 817
René Thierbach is an academic researcher from University of Jena. The author has contributed to research in topics: Frataxin & DNA damage. The author has an hindex of 12, co-authored 20 publications receiving 720 citations. Previous affiliations of René Thierbach include University of Veterinary Medicine Vienna & Schiller International University.
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Journal ArticleDOI
Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.
Tim J. Schulz,René Thierbach,Anja Voigt,Gunnar Drewes,Brun H. Mietzner,Pablo Steinberg,Andreas Pfeiffer,Michael Ristow,Michael Ristow +8 more
TL;DR: The view that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals is supported.
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Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
René Thierbach,Tim J. Schulz,Frank Isken,Aanja Voigt,Brun H. Mietzner,Gunnar Drewes,Jürgen-Christoph von Kleist-Retzow,Rudolf J. Wiesner,Mark A. Magnuson,Hélène Puccio,Andreas Pfeiffer,Pablo Steinberg,Michael Ristow +12 more
TL;DR: Findings indicate that frataxin may act as a mitochondrial tumor suppressor protein in mammals by promoting both apoptosis and proliferation in murine hepatocytes.
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Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice.
Antje Banning,Anna P. Kipp,Stephanie Schmitmeier,Maria Löwinger,Simone Florian,Susanne Krehl,Sophie Thalmann,René Thierbach,Pablo Steinberg,Regina Brigelius-Flohé +9 more
TL;DR: The data show that GPx2 inhibits malignant characteristics of tumor cells, such as migration and invasion, obviously by counteracting COX-2 expression but is required for the growth of transformed intestinal cells and may, therefore, facilitate tumor cell growth.
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Activation of mitochondrial energy metabolism protects against cardiac failure
Tim J. Schulz,Dirk Westermann,Frank Isken,Anja Voigt,Beate Laube,René Thierbach,Doreen Kuhlow,Kim Zarse,Lutz Schomburg,Andreas Pfeiffer,Carsten Tschöpe,Michael Ristow +11 more
TL;DR: Increased mitochondrial metabolism elicits an adaptive response due to mildly increased oxidative stress as a consequence of increased oxidative energy conversion, previously named mitohormesis, which activates protective mechanisms which counteract cardiotoxic stress and promote survival in states of experimental cardiomyopathy.
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Inhibition of Alanine Aminotransferase in Silico and in Vivo Promotes Mitochondrial Metabolism to Impair Malignant Growth
Gregor Beuster,Kim Zarse,Christoph Kaleta,René Thierbach,Michael Kiehntopf,Pablo Steinberg,Stefan Schuster,Michael Ristow +7 more
TL;DR: It is suggested that inhibition of ALAT efficiently impairs cancer growth by counteracting the Warburg effect due to compensatory activation of mitochondrial metabolism.