Doreen Kuhlow

TL;DR: Impaired insulin and IGF-1 signaling in C. elegans daf-2 mutants extends life span more than 2-fold and promotes L-proline metabolism to generate a ROS signal for the adaptive induction of endogenous stress defense to extend life span.

TL;DR: This work identifies a previously unknown C. elegans nicotinamide-N-methyltransferase, encoded by a gene now named anmt-1, to generate MNA from NAM, providing an unexpected mechanistic role for sirtuins beyond histone deacetylation.

TL;DR: Evidence is provided that GlcN extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet and promotes increased formation of mitochondrial reactive oxygen species (ROS) culminating in increased expression of the nematodal amino acid-transporter 1 (aat-1) gene.

TL;DR: In this article, the Terc subunit of the telomerase was found to exhibit impaired glucose tolerance in young adult mice, which is caused by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets.

TL;DR: Low‐dose arsenite extends lifespan in the nematode C. elegans, providing evidence for nonlinear dose‐response characteristics of toxin‐mediated stress resistance and longevity in a multicellular organism.