G
Gunter G. C. Kuhnle
Researcher at University of Reading
Publications - 155
Citations - 9781
Gunter G. C. Kuhnle is an academic researcher from University of Reading. The author has contributed to research in topics: Population & Acceptable daily intake. The author has an hindex of 45, co-authored 142 publications receiving 8385 citations. Previous affiliations of Gunter G. C. Kuhnle include Leipzig University & Wolfson Centre for Age-Related Diseases.
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Journal ArticleDOI
Interaction between flavonoids and the blood-brain barrier: in vitro studies.
Kuresh A. Youdim,Michael S. Dobbie,Gunter G. C. Kuhnle,Anna R. Proteggente,N. Joan Abbott,Catherine Rice-Evans +5 more
TL;DR: It is demonstrated that flavonoids and some metabolites are able to traverse the blood–brain barrier (BBB) and that the potential for permeation is consistent with compound lipophilicity.
Journal ArticleDOI
The metabolic fate of dietary polyphenols in humans.
A. Rechner,Gunter G. C. Kuhnle,Paul Bremner,Gary P. Hubbard,Kevin P. Moore,Catherine Rice-Evans +5 more
TL;DR: The results show that the majority of the in vivo forms derive from cleavage products of the action of colonic bacterial enzymes and subsequent metabolism in the liver, and suggest that consideration should be given to the cleavage Products as having a putative role as physiologically relevant bioactive components in vivo.
Journal ArticleDOI
Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products.
A. Rechner,Martin Smith,Gunter G. C. Kuhnle,Glenn R. Gibson,Edward S. Debnam,S. Kaila Srai,Kevin P. Moore,Catherine Rice-Evans +7 more
TL;DR: In this paper, the metabolism of chlorogenic acid, naringin, and rutin, representative members of three common families of dietary polyphenols, the hydroxycinnamates, the flavanones, and the flavonols, respectively, was studied in an in vitro mixed culture model of the human colonic microflora.
Original Contribution COLONIC METABOLISM OF DIETARY POLYPHENOLS: INFLUENCE OF STRUCTURE ON MICROBIAL FERMENTATION PRODUCTS
A. Rechner,Martin Smith,Gunter G. C. Kuhnle,Glenn R. Gibson,Edward S. Debnam,S. Kaila Srai,Kevin P. Moore,Catherine Rice-Evans +7 more
TL;DR: The results support extensive metabolism of dietary polyphenols in the colon, depending on substrate concentration and residence time, with resultant formation of simple phenolics, which can be considered biomarkers of colonic metabolism if subsequently absorbed.
Journal ArticleDOI
Flavanol monomer-induced changes to the human faecal microflora.
Xenofon Tzounis,Jelena Vulevic,Gunter G. C. Kuhnle,Trevor George,Jadwiga Leonczak,Glenn R. Gibson,Catherine L. Kwik-Uribe,Jeremy P. E. Spencer +7 more
TL;DR: Data suggest that the consumption of flavanol-rich foods may support gut health through their ability to exert prebiotic actions, as both ( − )-epicatechin and (+)-catechin were converted to the same metabolites.