G
Gunther Helms
Researcher at Lund University
Publications - 126
Citations - 6017
Gunther Helms is an academic researcher from Lund University. The author has contributed to research in topics: Flip angle & Magnetization transfer. The author has an hindex of 41, co-authored 121 publications receiving 5124 citations. Previous affiliations of Gunther Helms include University of Göttingen & University of Tübingen.
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Journal ArticleDOI
Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism
Sylvia Stockler,U. Holzbach,Folker Hanefeld,I. Marquardt,Gunther Helms,Martin Requart,Wolfgang Hänicke,Jens Frahm +7 more
TL;DR: In this article, a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in vivo proton magnetic resonance spectroscopy disclosed a generalized depletion of creatine in the brain.
Journal ArticleDOI
Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)
Bogdan Draganski,John Ashburner,Chloe Hutton,Ferat Kherif,Ferat Kherif,Richard S. Frackowiak,Gunther Helms,Nikolaus Weiskopf +7 more
TL;DR: The VBQ approach is presented, based on current biophysical models, as a fingerprint of age-dependent brain atrophy and underlying microstructural changes in myelin, iron deposits and water and extends current methods for detection of neurodegenerative processes in the brain.
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High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity and T1 relaxation obtained from 3D FLASH MRI.
TL;DR: The MT saturation appeared to be a sensitive parameter to depict MS lesions and alterations of normal‐appearing white matter in the brain due to clearly separated distributions for white and gray matter and cerebrospinal fluid.
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Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging
Martina F. Callaghan,Patrick Freund,Patrick Freund,Patrick Freund,Bogdan Draganski,Elaine J. Anderson,Marinella Cappelletti,Marinella Cappelletti,Rumana Chowdhury,Joern Diedrichsen,Thomas H. B. FitzGerald,Peter Smittenaar,Gunther Helms,Antoine Lutti,Nikolaus Weiskopf +14 more
TL;DR: This study aims to characterize the spatial pattern and age-related differences of biologically relevant measures in vivo over the course of normal aging and build a quantitative baseline from which to examine and draw a dividing line between healthy aging and pathologic neurodegeneration.
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Folate Receptor Alpha Defect Causes Cerebral Folate Transport Deficiency: A Treatable Neurodegenerative Disorder Associated with Disturbed Myelin Metabolism
Robert Steinfeld,Marcel Grapp,Ralph Kraetzner,Steffi Dreha-Kulaczewski,Gunther Helms,Peter Dechent,Ron A. Wevers,Salvatore Grosso,Jutta Gärtner +8 more
TL;DR: This work has identified an inherited brain-specific folate transport defect that is caused by mutations in the FOLR1 gene coding for folate receptor alpha (FRalpha) and provides new insights into the folate metabolic pathways involved in postnatal myelination and brain development.