G
Guo-Hua Fong
Researcher at University of Connecticut Health Center
Publications - 77
Citations - 10273
Guo-Hua Fong is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: Angiogenesis & Hypoxia-inducible factors. The author has an hindex of 36, co-authored 73 publications receiving 9546 citations. Previous affiliations of Guo-Hua Fong include University of Connecticut & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Guo-Hua Fong,Janet Rossant,Janet Rossant,Marina Gertsenstein,Martin L. Breitman,Martin L. Breitman +5 more
TL;DR: It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.
Journal ArticleDOI
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
Daniel J. Dumont,Gérard Gradwohl,Guo-Hua Fong,Mira C. Puri,Marina Gertsenstein,A. Auerbach,Martin L. Breitman +6 more
TL;DR: Observations demonstrate that the Tek signaling pathway plays a critical role in the differentiation, proliferation, and survival of endothelial cells in the mouse embryo.
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Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development
Daniel J. Dumont,Guo-Hua Fong,Mira C. Puri,Mira C. Puri,Gérard Gradwohl,Kari Alitalo,Martin L. Breitman,Martin L. Breitman +7 more
TL;DR: A possible dual role for VEGF which includes a chemotactic and/or a cellular maintenance role forVEGF during vascularization of the mouse embryo is suggested.
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Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
TL;DR: It is a surprising finding that it is an increase in the number of endothelial progenitors that leads to the vascular disorganization in flt-1(-/-) mice and the importance of population density of progenitor cells in pattern formation is demonstrated.
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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling.
TL;DR: It is suggested that EPAS-1 plays an important role at postvasculogenesis stages and is required for the remodeling of the primary vascular network into a mature hierarchy pattern.