M
Marina Gertsenstein
Researcher at Mount Sinai Hospital, Toronto
Publications - 146
Citations - 22517
Marina Gertsenstein is an academic researcher from Mount Sinai Hospital, Toronto. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 36, co-authored 142 publications receiving 21728 citations. Previous affiliations of Marina Gertsenstein include University of Toronto & Lunenfeld-Tanenbaum Research Institute.
Papers
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Journal ArticleDOI
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Peter Carmeliet,Valérie Ferreira,Georg Breier,Saskia Pollefeyt,Lena Kieckens,Marina Gertsenstein,Michaela Fahrig,Ann Vandenhoeck,Kendraprasad Harpal,Carmen Eberhardt,Cathérine Declercq,Judy Pawling,Lieve Moons,Desire Collen,Werner Risau,Andras Nagy,Andras Nagy +16 more
TL;DR: It is reported that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of embryonic stem (ES) cells with tetraploid embryos (T-ES)16,17, and even more impaired in homozygous D1-VEGF- deficient (VDGF-/-) T-ES embryos, resulting in death at mid-gestation.
Journal ArticleDOI
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
Journal ArticleDOI
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Guo-Hua Fong,Janet Rossant,Janet Rossant,Marina Gertsenstein,Martin L. Breitman,Martin L. Breitman +5 more
TL;DR: It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.
Journal ArticleDOI
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Knut Woltjen,Iacovos P. Michael,Iacovos P. Michael,Paria Mohseni,Paria Mohseni,Ridham Desai,Ridham Desai,Maria Mileikovsky,Riikka H. Hämäläinen,Rebecca Cowling,Wei Wang,Pentao Liu,Marina Gertsenstein,Keisuke Kaji,Hoon Ki Sung,Andras Nagy,Andras Nagy +16 more
TL;DR: It is shown that the individual PB insertions can be removed from established iPS cell lines, providing an invaluable tool for discovery, and the traceless removal of reprogramming factors joined with viral 2A sequences delivered by a single transposon from murine iPS lines is demonstrated.
Book
Manipulating the Mouse Embryo: A Laboratory Manual
TL;DR: This chapter discusses developmental Genetics and Embryology of the Mouse, including production of Transgenic and Chimeric Mice, and techniques for Visualizing Gene Products, Cells, Tissues, and Organ Systems.