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Guohua Xu
Researcher at Chinese Academy of Sciences
Publications - 25
Citations - 611
Guohua Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Chemistry. The author has an hindex of 13, co-authored 21 publications receiving 418 citations.
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Journal ArticleDOI
Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene
Shaoru Wang,Qiu-Yan Zhang,Jiaqi Wang,Xing-Yi Ge,Yanyan Song,Yafen Wang,Xiao-Dan Li,Boshi Fu,Guohua Xu,Bo Shu,Peng Gong,Bo Zhang,Tian Tian,Xiang Zhou +13 more
TL;DR: These findings provide the first evidence that G-quadruplex RNA is present in a negative-sense RNA virus and may represent a new therapeutic strategy against Ebola virus disease.
Journal ArticleDOI
A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target.
Shaoru Wang,Yuan-Qin Min,Jiaqi Wang,Chaoxing Liu,Boshi Fu,Fan Wu,Ling-Yu Wu,Zhi-Xian Qiao,Yanyan Song,Guohua Xu,Zhiguo Wu,Gai Huang,Nan-Fang Peng,Rong Huang,Wuxiang Mao,Shuang Peng,Yuqi Chen,Ying Zhu,Tian Tian,Xiao-Lian Zhang,Xiang Zhou +20 more
TL;DR: This work reveals highly conserved guanine-rich consensus sequences within the core gene of hepatitis C despite the high genetic variability of this ribovirus and provides direct evidences that small molecules specifically targeting G4 can stabilize this structure to reduce RNA replication and inhibit protein translation of intracellular hepatitis C.
Journal ArticleDOI
Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication
Wen-Xiu Bian,Yan Xie,Xiaoning Wang,Guohua Xu,Boshi Fu,Shu Li,Gang Long,Xiang Zhou,Xiao-Lian Zhang +8 more
TL;DR: These findings provide new insights that NCL may act as a host factor for anti-viral innate immunity, and binding of cellular NCL with the viral core RNA G4 structure is involved in suppressing HCV replication.
Journal ArticleDOI
Structure-guided post-SELEX optimization of an ochratoxin A aptamer.
TL;DR: The results demonstrate that the structure-guided post-SELEX approach improves aptamers affinity, and an improved OTA biosensor system might be developed using this new strategy.
Journal ArticleDOI
DNA quadruplexes as molecular scaffolds for controlled assembly of fluorogens with aggregation-induced emission
TL;DR: Tetrapod DNA quadruplexes were designed for assembly and precise modulation of light emission of an oligonucleotide-grafted fluorogen with aggregation-induced emission.