G
Guojun Zhao
Researcher at University of British Columbia
Publications - 17
Citations - 1383
Guojun Zhao is an academic researcher from University of British Columbia. The author has contributed to research in topics: Multiple sclerosis & Lesion. The author has an hindex of 11, co-authored 17 publications receiving 1286 citations. Previous affiliations of Guojun Zhao include Vancouver General Hospital.
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Journal Article
TNF neutralization in MS - Results of a randomized, placebo-controlled multicenter study
Arnason Bgw.,G Jacobs,M Hanlon,B H Clay,Noronha Abc.,A Auty,B Davis,Avindra Nath,Jean-Pierre Bouchard,C Belanger,F Gosselin,Manon Thibault,Pierre Duquette,P Bourgoin,Rebecca M. DuBois,M. Girard,George C. Ebers,Rice Gpa.,Margaret K. Vandervoort,Gordon S. Francis,L Duncan,Yves Lapierre,M. S. Freedman,S N Christie,Hyman Rabinovitch,David G. Patry,W F Murphy,S Peters,S D McGuiness,T J Murray,Virender Bhan,Charles Maxner,R. A. Van Dorpe,J J Oger,J. Nelson,W. Morrison,N Bogle,S Beall,G Vorobeychick,A V Hiltbrunner,J Bock,W Lesslauer,Li Dkb.,Donald W. Paty,Guojun Zhao,Grp Lmss.,Grp Ubcmsmria. +46 more
TL;DR: Lenercept failed to be beneficial, but insight into the role of TNF in MS exacerbations was gained.
Journal ArticleDOI
Correlations between changes in disability and T2‐weighted brain MRI activity in multiple sclerosis: A follow‐up study
Massimo Filippi,Donald W. Paty,Ludwig Kappos,Frederik Barkhof,D. A. S. Compston,Alan J. Thompson,Guojun Zhao,C. M. Wiles,W. I. McDonald,DH Miller +9 more
TL;DR: It is suggested that brain T2--weighted MRI is a useful supplementary marker of disease activity in definitive (phase 111) clinical treatment trials in MS.
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Dirty-appearing white matter in multiple sclerosis: preliminary observations of myelin phospholipid and axonal loss.
G. R. W. Moore,G. R. W. Moore,Cornelia Laule,Alex L. MacKay,Esther Leung,D. K. B. Li,Guojun Zhao,Anthony Traboulsee,Anthony Traboulsee,Donald W. Paty,Donald W. Paty +10 more
TL;DR: The findings of this preliminary study suggest that DAWM is characterized by loss of myelin phospholipids, detected by the short T2 component, and axonal reduction.
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Diffusely Abnormal White Matter in Multiple Sclerosis: Further Histologic Studies Provide Evidence for a Primary Lipid Abnormality With Neurodegeneration
Cornelia Laule,Vlady Pavlova,Esther Leung,Guojun Zhao,Alex Mackay,Piotr Kozlowski,Anthony Traboulsee,David K.B. Li,David K.B. Li,G. R. Wayne Moore,G. R. Wayne Moore +10 more
TL;DR: A primary lipid abnormality in DAWM that exceeds protein loss and is accompanied by axonal degeneration is suggested, which may be important in MS pathogenesis and disease progression, which is prominent in individuals with D AWM.
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Effect of interferon β-1b in MS: Assessment of annual accumulation of PD/T2 activity on MRI
TL;DR: This annual accumulation activity analysis of lesion activity shows that the previously reported treatment effect seen on MRI scanning once every 6 weeks in a subcohort of the patients can also be seen on yearly scans, providing an independent MRI confirmation of a treatment and dose effect for IFNβ-1b.