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Guoqing Li
Researcher at Yangzhou University
Publications - 29
Citations - 881
Guoqing Li is an academic researcher from Yangzhou University. The author has contributed to research in topics: Fibroblast-like synoviocyte & Signal transduction. The author has an hindex of 15, co-authored 27 publications receiving 634 citations.
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Journal ArticleDOI
Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway.
Guoqing Li,Yu Zhang,Yayun Qian,Hua Zhang,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +7 more
TL;DR: A synergetic effect of IL-17A and hypoxia that might contribute to the migration and invasion of RA-FLSs by upregulating the expression of MMP2 and MMP9 by activation of the NF-κB/HIF-1α pathway is suggested.
Journal ArticleDOI
Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression
Guoqing Li,Dan Liu,Yu Zhang,Yayun Qian,Hua Zhang,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +8 more
TL;DR: Celastrol might inhibit FLS migration and invasion induced by LPS by suppressing TLR4/NF-κB-mediated MMP-9 expression, providing a theoretical foundation for the clinical treatment of RA with celastrol.
Journal ArticleDOI
PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
Guoqing Li,Yu Zhang,Dan Liu,Yayun Qian,Hua Zhang,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +8 more
TL;DR: Results of this study suggest that activation of the PI3K/Akt/HIF-1α pathway plays a pivotal role in mediating hypoxia-induced EMT transformation and invasion of RA-FLSs under Hypoxia.
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LncRNA MEG3 inhibits rheumatoid arthritis through miR-141 and inactivation of AKT/mTOR signalling pathway.
Guoqing Li,Ying Liu,Ying Liu,Fanru Meng,Fanru Meng,Zhongbin Xia,Xia Wu,Xia Wu,Yuxuan Fang,Yuxuan Fang,Chunwang Zhang,Chunwang Zhang,Yu Zhang,Dan Liu +13 more
TL;DR: The protective role of MEG3 in RA was proved to be exerted by the increase in the rate of proliferation, which might correlate to the regulatory role of miR‐141 and AKT/mTOR signal pathway, suggesting that MEG 3 holds great promise as a therapeutic strategy for RA.
Journal ArticleDOI
Inhibition of NF-κB signaling pathway induces apoptosis and suppresses proliferation and angiogenesis of human fibroblast-like synovial cells in rheumatoid arthritis.
Zhong-Bin Xia,Fanru Meng,Fanru Meng,Yuxuan Fang,Yuxuan Fang,Xia Wu,Xia Wu,Chunwang Zhang,Chunwang Zhang,Ying Liu,Ying Liu,Dan Liu,Guoqing Li,Fan-Bo Feng,Hai-Yang Qiu +14 more
TL;DR: It is concluded that inhibition of NF-&kgr;B pathway induced cell apoptosis and suppressed proliferation and angiogenesis of RA-HFLS, which could serve as a novel target in the treatment of RA.