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Yayun Qian
Researcher at Yangzhou University
Publications - 52
Citations - 945
Yayun Qian is an academic researcher from Yangzhou University. The author has contributed to research in topics: Medicine & Apoptosis. The author has an hindex of 15, co-authored 37 publications receiving 714 citations.
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Journal ArticleDOI
Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway.
Guoqing Li,Yu Zhang,Yayun Qian,Hua Zhang,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +7 more
TL;DR: A synergetic effect of IL-17A and hypoxia that might contribute to the migration and invasion of RA-FLSs by upregulating the expression of MMP2 and MMP9 by activation of the NF-κB/HIF-1α pathway is suggested.
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Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression
Guoqing Li,Dan Liu,Yu Zhang,Yayun Qian,Hua Zhang,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +8 more
TL;DR: Celastrol might inhibit FLS migration and invasion induced by LPS by suppressing TLR4/NF-κB-mediated MMP-9 expression, providing a theoretical foundation for the clinical treatment of RA with celastrol.
Journal ArticleDOI
Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.
Lin Yang,Yanqing Liu,Mei Wang,Yayun Qian,Xiaoyun Dong,Hao Gu,Haibo Wang,Shiyu Guo,Tadashi Hisamitsu +8 more
TL;DR: It was determined that quercetin inhibited HT-29 cell viability in a dose-dependent manner, and the overexpression of CSN6 reduced the effect of quercETin treatment on HT- 29 cells, suggesting that quERCetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-28 cells.
Journal ArticleDOI
PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
Guoqing Li,Yu Zhang,Dan Liu,Yayun Qian,Hua Zhang,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +8 more
TL;DR: Results of this study suggest that activation of the PI3K/Akt/HIF-1α pathway plays a pivotal role in mediating hypoxia-induced EMT transformation and invasion of RA-FLSs under Hypoxia.
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Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma
Yaodong Zhu,Yanqing Liu,Yayun Qian,Xiaojun Dai,Ling Yang,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +7 more
TL;DR: It is suggested that COE inhibits the EMT by suppressing the expression of HSP27, correlating with inhibition of NF-κB/Snail signal pathways in SGC-7901 cells, and may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.