G
Gustavo Bonacci
Researcher at National University of Cordoba
Publications - 34
Citations - 1999
Gustavo Bonacci is an academic researcher from National University of Cordoba. The author has contributed to research in topics: Nitration & Fatty acid. The author has an hindex of 20, co-authored 33 publications receiving 1815 citations. Previous affiliations of Gustavo Bonacci include Pasteur Institute & University of Pittsburgh.
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Journal ArticleDOI
Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids
Alison L. Groeger,Chiara Cipollina,Marsha P. Cole,Steven R. Woodcock,Gustavo Bonacci,Tanja K. Rudolph,Volker Rudolph,Bruce A. Freeman,Francisco J. Schopfer +8 more
TL;DR: The data support the idea that EFOX are signaling mediators that transduce the beneficial clinical effects of omega-3 fatty acids, COX-2 and aspirin, and confirm the anti-inflammatory nature of DHA- and DPA-derived EFOX.
Journal ArticleDOI
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism
Emilia Kansanen,Gustavo Bonacci,Francisco J. Schopfer,Suvi M. Kuosmanen,Kit I. Tong,Hanna Leinonen,Steven R. Woodcock,Masayuki Yamamoto,Carsten Carlberg,Carsten Carlberg,Seppo Ylä-Herttuala,Bruce A. Freeman,Anna-Liisa Levonen +12 more
TL;DR: Unlike many other Nrf2-activating electrophiles, OA-NO2 enhanced rather than diminished the binding between Keap1 and the Cul3 subunit of the E3 ligase for NRF2, which can influence the pattern of gene expression and therapeutic actions of nitroalkenes.
Journal ArticleDOI
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.
Volker Rudolph,Volker Rudolph,Tanja K. Rudolph,Tanja K. Rudolph,Francisco J. Schopfer,Gustavo Bonacci,Steven R. Woodcock,Marsha P. Cole,Paul R. S. Baker,Ravi Ramani,Bruce A. Freeman +10 more
TL;DR: This study reveals the de novo generation of fatty acid nitration products in vivo and reveals the anti-inflammatory and potential therapeutic actions of OA-NO(2) in myocardial I/R injury.
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Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids SELECTIVE LIGAND ACTIVITY AND ANTI-DIABETIC SIGNALING ACTIONS
Francisco J. Schopfer,Marsha P. Cole,Alison L. Groeger,Chen Shan Chen,Nicholas K.H. Khoo,Steven R. Woodcock,Franca Golin-Bisello,U. Nkiru Motanya,Yong Li,Jifeng Zhang,Minerva Garcia-Barrio,Tanja K. Rudolph,Volker Rudolph,Gustavo Bonacci,Paul R. S. Baker,H. Eric Xu,Carlos Batthyány,Y. Eugene Chen,Tina M. Hallis,Bruce A. Freeman +19 more
TL;DR: Administration of this class of signaling mediators to ob/ob mice revealed that NO(2)-FA lower insulin and glucose levels without inducing adverse side effects such as the increased weight gain induced by TZDs.
Journal ArticleDOI
Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration
Gustavo Bonacci,Paul R. S. Baker,Sonia R. Salvatore,Darla Shores,Nicholas K.H. Khoo,Jeffrey R. Koenitzer,Dario A. Vitturi,Steven R. Woodcock,Franca Golin-Bisello,Marsha P. Cole,Simon C. Watkins,Claudette M. St. Croix,Carlos Batthyány,Bruce A. Freeman,Francisco J. Schopfer +14 more
TL;DR: Conjugated linoleic acid (CLA) is identified as the primary endogenous substrate for fatty acid nitration in vitro and in vivo, yielding up to 105 greater extent of nitration products as compared with bis-allylic linolesic acid, affirm that metabolic and inflammatory reactions yield electrophilic products that can modulate adaptive cell signaling mechanisms.