G
Gyun Min Lee
Researcher at KAIST
Publications - 297
Citations - 20834
Gyun Min Lee is an academic researcher from KAIST. The author has contributed to research in topics: Chinese hamster ovary cell & Cell culture. The author has an hindex of 51, co-authored 290 publications receiving 17730 citations. Previous affiliations of Gyun Min Lee include University of Michigan & Novo Nordisk Foundation.
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Clonal variability within dihydrofolate reductase-mediated gene amplified Chinese hamster ovary cells: stability in the absence of selective pressure.
TL;DR: The subclones with high qAb were relatively stable with regard to antibody production during long-term culture in the absence of selective pressure (P < 0. 005, ANOVA), and the clonal heterogeneity in an amplified CHO cell population necessitates clonal analysis for screening stable clones with highqAb.
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Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production
No Soo Kim,Gyun Min Lee +1 more
TL;DR: In this article, a survival protein, human Bcl-2, was overexpressed in recombinant Chinese hamster ovary (CHO) cells (SH2-0.32), producing a humanized antibody directed against the S surface antigen of hepatitis B virus.
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Long-Term and Sustained COMP-Ang1 Induces Long-Lasting Vascular Enlargement and Enhanced Blood Flow
Chung-Hyun Cho,Kyung Eun Kim,Jonghoe Byun,Hyung Suk Jang,Duk Kyung Kim,Peter Baluk,Fabienne Baffert,Gyun Min Lee,Naoki Mochizuki,Jin Kim,Byeong Hwa Jeon,Donald M. McDonald,Gou Young Koh +12 more
TL;DR: It is found that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow and that sustained overexpression of Tie2 could participate in the maintenance of vascular changes.
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Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system.
Bernhard O. Palsson,Se-Hwan Paek,Richard M. Schwartz,Mahshid A. Palsson,Gyun Min Lee,Gyun Min Lee,Samuel M. Silver,Stephen G. Emerson +7 more
TL;DR: A continuous perfusion bioreactor system that enables a population of unselected human mononuclear bone marrow cells obtained from adult donors to expand up to 20 to 25-fold over a two-week period is described.
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Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells.
TL;DR: The results obtained demonstrate the potential of YH as a medium additive for hTPO production in serum-free suspension cultures of rCHO cells and minimize degradation of h TPO susceptible to proteolytic degradation.