H
H. D. Perez
Publications - 5
Citations - 911
H. D. Perez is an academic researcher. The author has contributed to research in topics: Chemokine receptor & CCR1. The author has an hindex of 5, co-authored 5 publications receiving 897 citations.
Papers
More filters
Journal Article
Expression of chemokine receptors by subsets of neurons in the central nervous system.
Richard Horuk,A. W. Martin,Z.-X. Wang,L. Schweitzer,A. Gerassimides,H. Guo,Zhao-Hai Lu,Joseph Hesselgesser,H. D. Perez,J. Kim,J. Parker,Terence J. Hadley,Stephen C. Peiper +12 more
TL;DR: Immunohistochemical analysis of the involved brain tissues from patients with Alzheimer's disease revealed expression of CXCR2 in the neuritic portion of plaques surrounding deposits of amyloid, suggesting that chemokines may play a role in reactive processes in normal neuronal function and neurodegenerative disorders.
Journal ArticleDOI
Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model.
D A Barnes,J Tse,M Kaufhold,M Owen,Joseph Hesselgesser,Robert M. Strieter,Richard Horuk,H. D. Perez +7 more
TL;DR: RANTES expression plays an important role in the disease since a polyclonal antibody to RANTES greatly ameliorated symptoms in animals induced for AIA and was found to be as efficacious as treatment with indomethacin, a non-steroidal anti inflammatory.
Journal ArticleDOI
Identification and Characterization of Small Molecule Functional Antagonists of the CCR1 Chemokine Receptor
Joseph Hesselgesser,Ng Howard P,M. Liang,Wei Zheng,Karen May,John G. Bauman,Monahan Sean D,Imadul Islam,Guo Ping Wei,Ghannam Ameen F,Dennis D. Taub,Mary Rosser,R. M. Snider,Michael M. Morrissey,H. D. Perez,Richard Horuk +15 more
TL;DR: This is the first description of C CR1 receptor antagonists that may be useful in the treatment of chronic inflammatory diseases involving MIP-1α, RANTES, and CCR1.
Journal ArticleDOI
Discovery of novel non-peptide CCR1 receptor antagonists.
Ng Howard P,Karen May,John G. Bauman,Ghannam Ameen F,Imadul Islam,M. Liang,Richard Horuk,Joseph Hesselgesser,R. M. Snider,H. D. Perez,Michael M. Morrissey +10 more
TL;DR: A novel series of 4-hydroxypiperidines has been discovered by high throughput screening (HTS) which potently inhibits the binding of MIP-1alpha and RANTES to the recombinant human CCR1 chemokine receptor.
Journal ArticleDOI
Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor
M. Liang,Mary Rosser,Ng Howard P,Karen May,John G. Bauman,Imadul Islam,Ghannam Ameen F,P. J. Kretschmer,Haifeng Pu,Laura Dunning,R. M. Snider,Michael M. Morrissey,Joseph Hesselgesser,H. D. Perez,Richard Horuk +14 more
TL;DR: The species specificity of a small molecule antagonist for the human CCR1 chemokine receptor, 2-2-diphenyl-5-(4-chlorophenyl)piperidin-1-yl)valeronitrile (CCR1 antagonist 1), has been examined and suggested that the antagonist binding site is well-conserved in rabbit, marmoset and human C CR1, but not in mouse CCR 1.