S
Stephen C. Peiper
Researcher at Thomas Jefferson University
Publications - 159
Citations - 11263
Stephen C. Peiper is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Chemokine receptor & Chemokine. The author has an hindex of 53, co-authored 157 publications receiving 10730 citations. Previous affiliations of Stephen C. Peiper include St. Marianna University School of Medicine & Children's National Medical Center.
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Journal ArticleDOI
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
Benjamin J. Doranz,Joseph Rucker,Yanjie Yi,Robert J. Smyth,Michel Samson,Stephen C. Peiper,Marc Parmentier,Ronald G. Collman,Robert W. Doms +8 more
TL;DR: The results suggest that the T- Tropic viruses characteristic of disease progression may evolve from purely M-tropic viruses prevalent early in virus infection through changes in the env protein that enable the virus to use multiple entry cofactors.
Journal Article
Expression of chemokine receptors by subsets of neurons in the central nervous system.
Richard Horuk,A. W. Martin,Z.-X. Wang,L. Schweitzer,A. Gerassimides,H. Guo,Zhao-Hai Lu,Joseph Hesselgesser,H. D. Perez,J. Kim,J. Parker,Terence J. Hadley,Stephen C. Peiper +12 more
TL;DR: Immunohistochemical analysis of the involved brain tissues from patients with Alzheimer's disease revealed expression of CXCR2 in the neuritic portion of plaques surrounding deposits of amyloid, suggesting that chemokines may play a role in reactive processes in normal neuronal function and neurodegenerative disorders.
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CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.
Joseph Hesselgesser,Meredith Halks-Miller,Virginia DelVecchio,Stephen C. Peiper,James A. Hoxie,Dennis L. Kolson,Dennis D. Taub,Richard Horuk +7 more
TL;DR: These data support recent findings that members of the chemokine family, including CCR5 and LESTR/Fusin (CXCR4), function as coreceptors in combination with CD4 for HIV-1 invasion.
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CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.
Jolanta Libura,Justyna Drukala,Marcin Majka,Oana Tomescu,Jean Marc Navenot,Magdalena Kucia,Leah A. Marquez,Stephen C. Peiper,Frederic G. Barr,Anna Janowska-Wieczorek,Mariusz Z. Ratajczak +10 more
TL;DR: It is suggested that the CXCR4-SDF-1 axis may play an important role in tumor spread and metastasis of RMS cells to bone marrow and that molecular strategies aimed at inhibiting this axis could thus prove to be useful therapeutic measures.
Journal ArticleDOI
Regulation of human chemokine receptors CXCR4: Role of phosphorylation in desensitization and internalization
Bodduluri Haribabu,Ricardo M. Richardson,Ian Fisher,Silvano Sozzani,Stephen C. Peiper,Richard Horuk,Hydar Ali,Ralph Snyderman +7 more
TL;DR: Signaling and internalization of CXCR4 are regulated by receptor phosphorylation dependent and independent mechanisms, indicating independent regulatory pathways for these processes.