H
H. Jelger Risselada
Researcher at University of Göttingen
Publications - 31
Citations - 7382
H. Jelger Risselada is an academic researcher from University of Göttingen. The author has contributed to research in topics: Membrane & Biology. The author has an hindex of 17, co-authored 21 publications receiving 6347 citations. Previous affiliations of H. Jelger Risselada include Leiden University & Max Planck Society.
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The MARTINI force field : Coarse grained model for biomolecular simulations
TL;DR: An improved and extended version of the coarse grained lipid model is presented, coined the MARTINI force field, based on the reproduction of partitioning free energies between polar and apolar phases of a large number of chemical compounds to reproduce the free energies of these chemical building blocks.
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Membrane protein sequestering by ionic protein–lipid interactions
Geert van den Bogaart,Karsten Meyenberg,H. Jelger Risselada,Hayder Amin,Katrin I. Willig,Barbara E. Hubrich,Markus Dier,Stefan W. Hell,Helmut Grubmüller,Ulf Diederichsen,Reinhard Jahn +10 more
TL;DR: The results demonstrate that electrostatic protein–lipid interactions can result in the formation of microdomains independently of cholesterol or lipid phases.
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The molecular face of lipid rafts in model membranes.
TL;DR: A simulation model is applied to assess the molecular nature of domains formed in ternary mixtures, showing the spontaneous separation of a saturated phosphatidylcholine (PC)/unsaturated PC/cholesterol mixture into a liquid-ordered and aLiquid-disordered phase with structural and dynamic properties closely matching experimental data.
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The molecular mechanism of lipid monolayer collapse.
TL;DR: This work investigates the molecular mechanism of monolayer collapse using molecular dynamics simulations and finds that transformation into a vesicle reduces the energy of the fold perimeter and is facilitated for softer bilayers, e.g., those with a higher content of unsaturated lipids, or at higher temperatures.
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Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
Alf Honigmann,Geert van den Bogaart,Geert van den Bogaart,Emilio Iraheta,H. Jelger Risselada,Dragomir Milovanovic,Veronika Mueller,Stefan Müllar,Ulf Diederichsen,Dirk Fasshauer,Helmut Grubmüller,Stefan W. Hell,Christian Eggeling,Christian Eggeling,Karin Kühnel,Reinhard Jahn +15 more
TL;DR: The results suggest that PIP2 clusters organized by syntaxin-1 act as molecular beacons for vesicle docking, with the subsequent Ca2+ influx bringing the vesicles membrane close enough for membrane fusion.