H
H. Kalervo Väänänen
Researcher at University of Turku
Publications - 87
Citations - 6378
H. Kalervo Väänänen is an academic researcher from University of Turku. The author has contributed to research in topics: Bone resorption & Osteoclast. The author has an hindex of 45, co-authored 87 publications receiving 6058 citations. Previous affiliations of H. Kalervo Väänänen include University of Eastern Finland & University of Helsinki.
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Journal ArticleDOI
Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite
Petri Lehenkari,Maarit Kellinsalmi,Juha Näpänkangas,Kari Ylitalo,Jukka Mönkkönen,Michael J. Rogers,Alex Azhayev,H. Kalervo Väänänen,Ilmo E. Hassinen +8 more
TL;DR: Inhibition of the ADP/ATP translocase by the metabolite AppCCl(2)p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption in isolated human osteoclasts.
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Biochemical markers of bone metabolism and prediction of fracture in elderly women.
Paul Gerdhem,Kaisa K. Ivaska,Sari L. Alatalo,Jussi M. Halleen,Jukka Hellman,Anders Isaksson,Kim Pettersson,H. Kalervo Väänänen,Kristina Åkesson,Karl Obrant +9 more
TL;DR: In elderly women, TRACP5b and urinary fragments of osteocalcin are promising new markers for prediction of fracture, in particular, vertebral fracture.
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Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase.
Jussi M. Halleen,Seija R. Räisänen,Jari Salo,Sakamuri V. Reddy,G. David Roodman,Teuvo Hentunen,Petri Lehenkari,Helena Kaija,Pirkko Vihko,H. Kalervo Väänänen +9 more
TL;DR: It is shown that TRAP can generate ROS in vitro and that cells over-expressing TRAP produce higher amounts of intracellular ROS than their parent cells, and proposed that proteins containing redox-active iron could represent a novel mechanism of physiological fragmentation of organic molecules.
Journal ArticleDOI
Osteoclast lineage and function
TL;DR: Detailed molecular knowledge of osteoclast differentiation and function has helped to identify several target molecules and develop specific treatments to inhibit pathological bone resorption in various skeletal diseases.
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Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis
Seija R. Räisänen,Petri Lehenkari,Merja J. Tasanen,Paavo Rahkila,Pirkko Härkönen,H. Kalervo Väänänen +5 more
TL;DR: The results suggest that CA III functions as an oxyradical scavenger and thus protects cells from oxidative damage and thusprotects cells from hydrogen peroxide‐induced apoptosis.