Jussi M. Halleen

TL;DR: Serum TRAP 5b activity decreased significantly after 6 months of hormone replacement therapy (HRT) of postmenopausal women compared with the change observed in post menopausal women receiving placebo, but no significant differences were observed between the changes in the placebo and HRT groups in total serum TRAP amount.

TL;DR: In elderly women, TRACP5b and urinary fragments of osteocalcin are promising new markers for prediction of fracture, in particular, vertebral fracture.

TL;DR: It is shown that TRAP can generate ROS in vitro and that cells over-expressing TRAP produce higher amounts of intracellular ROS than their parent cells, and proposed that proteins containing redox-active iron could represent a novel mechanism of physiological fragmentation of organic molecules.

TL;DR: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism, which may limit the accretion of bone mass in young girls.

TL;DR: This review summarizes the scientific knowledge on the role of TRACP in osteoclastic bone resorption, the mechanism ofTRACP 5b generation in osteoblasts and its secretion into the blood circulation, the methodology of measuring TRACP 5a, diagnostic evidence for the use of TRACP 5b as a resorptive marker, and characteristics of TR ACP 5a compared to other commonly used bone turnover markers.