H
H. Marquardt
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 6
Citations - 153
H. Marquardt is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: 7,12-Dimethylbenz[a]anthracene & Chinese hamster. The author has an hindex of 5, co-authored 6 publications receiving 153 citations. Previous affiliations of H. Marquardt include Institute of Cancer Research.
Papers
More filters
Journal ArticleDOI
Malignant transformation in vitro of mouse fibroblasts by 7,12-dimethylbenz(A)anthracene and 7-hydroxymethylbenz(A)anthracene and by their K-region derivatives.
H. Marquardt,H. Marquardt,J. E. Sodergren,J. E. Sodergren,P. Sims,P. Sims,P L Grover,P L Grover +7 more
TL;DR: In other experiments, the addition of α‐naphthoflavone was found to inhibit the formation of water‐soluble metabolites from and the toxicity of 7, 12‐dimethylbenz(a)anthracene without affecting malignant transformation.
Journal ArticleDOI
The metabolic activation of 7-methylbenz(a)anthracene: the induction of malignant transformation and mutation in mammalian cells by non-K-region dihydrodiols.
TL;DR: The data support the general hypothesis that non‐K‐region dihydrodiols, which can be metabolized to vicinal diol‐epoxides, are important in the metabolic activation of the carcinogenic polycyclic hydrocarbons.
Journal ArticleDOI
Induction of malignant transformation and mutagenesis by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene.
H. Marquardt,H. Marquardt,Stephanie Baker,Stephanie Baker,B. Tierney,B. Tierney,P L Grover,P L Grover,P. Sims,P. Sims +9 more
TL;DR: Both the 3,4- and the 8,9-diols derived from 7,12-dimethylbenz[a]anthracene induced mutations to 8-azaguanine resistance in V79 cells and malignant transformation in M2 mouse fibroblasts and were more active than the hydrocarbon itself.
Journal ArticleDOI
Metabolic activation of 3-methylcholanthrene: mutagenic and transforming activities of the 9,10-dihydrodiol.
Christian Malaveille,Helmut Bartsch,H. Marquardt,Stephanie Baker,B. Tierney,Alan Hewer,Philip L. Grover,Peter J. Sims +7 more
TL;DR: Results obtained indicate that the 9,10-dihydrodiol derived from 3-methylcholanthrene is involved, presumably following conversion into the corresponding vicinal diol-epoxide, 9, 10- dihydro-9-10-Dihydroxy-3- methylcholthrene 7,8-oxide, in the metabolic activation of this carcinogenic polycyclic hydrocarbon.
Journal ArticleDOI
Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene.
TL;DR: The results are not inconsistent with other data suggesting that the metabolic activation of both BA and DMBA occurs through conversion of the respective 3,4-dihydrodiols into the related vicinal diol-epoxides, although other dihydrodiolS may also be involved in vivo.