H
H. Matern
Researcher at RWTH Aachen University
Publications - 18
Citations - 652
H. Matern is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Bile acid & Microsome. The author has an hindex of 13, co-authored 18 publications receiving 639 citations.
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Journal ArticleDOI
Mutation of β-glucosidase 2 causes glycolipid storage disease and impaired male fertility
Yildiz Yildiz,H. Matern,Bonne M. Thompson,Jeremy C. Allegood,Rebekkah L. Warren,Denise M.O. Ramirez,Robert E. Hammer,F. Kent Hamra,Siegfried Matern,David W. Russell +9 more
TL;DR: It is concluded that GBA2 is a glucosylceramidase whose loss causes accumulation of glycolipids and an endoplasmic reticulum storage disease.
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Bile acid N-acetylglucosaminidation. In vivo and in vitro evidence for a selective conjugation reaction of 7 beta-hydroxylated bile acids in humans.
Hanns-Ulrich Marschall,H. Matern,Hubertus Wietholtz,Börje Egestad,Siegfried Matern,Jan Sjövall +5 more
TL;DR: These studies show that N-acetylglucosaminidation is a selective conjugation pathway for 7 beta-hydroxylated bile acids.
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Purification and Characterization of a Microsomal Bile Acid β-Glucosidase from Human Liver
TL;DR: Immunoinhibition and immunoprecipitation studies using antibodies prepared against lysosomal glucocerebrosidase showed no cross-reactivity with microsomal β-glucosidase suggesting that these two enzymes are antigenically unrelated.
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Evidence for bile acid glucosides as normal constituents in human urine.
TL;DR: A glucosyltransferase catalysing formation of bile acid glucosides was recently isolated from human liver microsomes and a method was devised for their isolation and purification from urine to investigate the potential occurrence of such bile Acid derivatives in vivo.
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Molecular Cloning and Expression of Human Bile Acid β-Glucosidase
TL;DR: Northern blot analysis of various human tissues revealed high levels of expression of the bile acid beta-glucosidase mRNA (3.6-kilobase message) in brain, heart, skeletal muscle, kidney, and placenta and lower levels ofexpression in the liver and other organs.