D
David W. Russell
Researcher at University of Texas Southwestern Medical Center
Publications - 221
Citations - 48001
David W. Russell is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gene & LDL receptor. The author has an hindex of 107, co-authored 204 publications receiving 44706 citations. Previous affiliations of David W. Russell include University of Texas Health Science Center at San Antonio & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
TL;DR: The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals and causes a spectrum of human disease; this ranges from liver failure in early childhood to progressive neuropathy in adults.
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Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Joseph L. Goldstein,Michael S. Brown,Richard G.W. Anderson,David W. Russell,Wolfgang J. Schneider +4 more
TL;DR: This data indicates that intracellular routes in the response of the immune system to EMT are regulated by Tournaisian reprograming, a type of ‘spatially aggregating’ behaviour.
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A comprehensive classification system for lipids
Eoin Fahy,Shankar Subramaniam,H. Alex Brown,Christopher K. Glass,Alfred H. Merrill,Robert C. Murphy,Christian R. H. Raetz,David W. Russell,Yousuke Seyama,Walter A. Shaw,Takao Shimizu,Friedrich Spener,Gerrit van Meer,Michael S. VanNieuwenhze,Stephen H. White,Joseph L. Witztum,Edward A. Dennis +16 more
TL;DR: A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
TL;DR: EPAS1 expression is limited to the endothelium of mouse embryos and is capable of specifically activating the transcription of the endothelial tyrosine kinase gene Tie-2, raising the possibility that EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia.
Journal ArticleDOI
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
Tokuo Yamamoto,C. Geoffrey Davis,Michael S. Brown,Wolfgang J. Schneider,M. Linette Casey,Joseph L. Goldstein,David W. Russell +6 more
TL;DR: Transfection of simian COS cells with the human LDL receptor cDNA linked to the SV40 early promoter resulted in expression of functional cell surface receptors.