S
Siegfried Matern
Researcher at RWTH Aachen University
Publications - 148
Citations - 5615
Siegfried Matern is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Bile acid & Cholestasis. The author has an hindex of 39, co-authored 148 publications receiving 5393 citations. Previous affiliations of Siegfried Matern include University of Texas at Austin.
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Journal ArticleDOI
Patients with acute on chronic liver failure display 'sepsis-like' immune paralysis
Hermann E. Wasmuth,Dagmar Kunz,Eray Yagmur,Annette Timmer-Stranghöner,Daniel Vidacek,Elmar Siewert,Jens Bach,Andreas Geier,Edmund Purucker,Axel M. Gressner,Siegfried Matern,Frank Lammert +11 more
TL;DR: Patients with ACLF and severe sepsis show a similar degree of cellular immune depression, which might contribute to the increased infectious morbidity of these patients and provide a rational basis for prevention strategies.
Journal ArticleDOI
Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management.
TL;DR: This work aims to provide a clear picture of the role of vaccination in the development of women’s gynecological prolapse and the importance of informed consent in the decision-making process.
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Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
S. Hillebrandt,S. Hillebrandt,Hermann E. Wasmuth,Ralf Weiskirchen,Claus Hellerbrand,H. Keppeler,H. Keppeler,Alexa Werth,R. Schirin-Sokhan,Gabriele Wilkens,Andreas Geier,Johann Lorenzen,Jörg Köhl,Axel M. Gressner,Siegfried Matern,Frank Lammert,Frank Lammert +16 more
TL;DR: The mouse quantitative trait gene led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that C5 has a causal role in fibrogenesis across species.
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Mutation of β-glucosidase 2 causes glycolipid storage disease and impaired male fertility
Yildiz Yildiz,H. Matern,Bonne M. Thompson,Jeremy C. Allegood,Rebekkah L. Warren,Denise M.O. Ramirez,Robert E. Hammer,F. Kent Hamra,Siegfried Matern,David W. Russell +9 more
TL;DR: It is concluded that GBA2 is a glucosylceramidase whose loss causes accumulation of glycolipids and an endoplasmic reticulum storage disease.
Journal ArticleDOI
Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Andreas Geier,Christoph G. Dietrich,Sebastian Voigt,Suk-Kyum Kim,Thomas Gerloff,Gerd A. Kullak-Ublick,Johann Lorenzen,Siegfried Matern,Carsten Gartung +8 more
TL;DR: TNF‐α represents the master cytokine responsible for HNF1‐dependent down‐regulation of Ntcp, Oatp1, and Oat p2 in CCl4‐induced toxic liver injury and H NF1 and RXR/RAR‐independent mechanisms appear to be more important in regulation of Mrp2 and NtCP gene expression in endotoxemia.