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H

H V Anderson

Researcher at The Texas Heart Institute

Publications -  10
Citations -  655

H V Anderson is an academic researcher from The Texas Heart Institute. The author has contributed to research in topics: Myocardial infarction & Artery. The author has an hindex of 6, co-authored 10 publications receiving 644 citations.

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Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries.

TL;DR: Test the hypothesis that endogenously produced nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries of mongrel dogs found it to be true, in both in vitro and ex vivo platelet studies.
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Frequency and severity of cyclic flow alternations and platelet aggregation predict the severity of neointimal proliferation following experimental coronary stenosis and endothelial injury.

TL;DR: In this paper, the role of recurrent platelet aggregation in the development of neointimal proliferation of coronary arteries was explored in 24 chronically instrumented dogs, and variable degrees of coronary artery proliferation were observed 3 weeks after mechanical injury of the arterial endothelium and the placement of an external coronary artery constrictor.
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Combination of inhibition of thrombin and blockade of thromboxane A2 synthetase and receptors enhances thrombolysis and delays reocclusion in canine coronary arteries.

TL;DR: Inhibition of thrombin in addition to treatment with t-PA enhances thrombolysis and delays or may prevent reocclusion of the recanalized coronary arteries.