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Claude R. Benedict
Researcher at University of Texas Health Science Center at Houston
Publications - 77
Citations - 5386
Claude R. Benedict is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Heart failure & Vascular smooth muscle. The author has an hindex of 34, co-authored 77 publications receiving 5229 citations. Previous affiliations of Claude R. Benedict include Tufts Medical Center & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
Guillermo Torre-Amione,Samir R. Kapadia,Claude R. Benedict,Hakan Oral,James B. Young,Douglas L. Mann +5 more
TL;DR: Circulating levels of proinflammatory cytokines increase in patients as their functional heart failure classification deteriorates, and activation of the neurohumoral axis is unlikely to completely explain the elaboration of pro inflammatory cytokines in heart failure.
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Effects of Long-term Enalapril Therapy on Cardiac Structure and Function in Patients With Left Ventricular Dysfunction: Results of the SOLVD Echocardiography Substudy
Barry H. Greenberg,Miguel A. Quinones,Chris Koilpillai,Marian C. Limacher,Daniel M. Shindler,Claude R. Benedict,Brent J. Shelton +6 more
TL;DR: These data demonstrate that enalapril attenuates progressive increases in LV dilatation and hypertrophy in patients with LV dysfunction and support the possibility that the favorable effects of en alapril reported in the SOLVD trials were related to inhibition of LV remodeling.
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Prognostic Significance of Plasma Norepinephrine in Patients With Asymptomatic Left Ventricular Dysfunction
Claude R. Benedict,Brent J. Shelton,David E. Johnstone,Gary S. Francis,Barry H. Greenberg,Marvin A. Konstam,Jeffrey L. Probstfield,Salim Yusuf +7 more
TL;DR: Increased PNE levels in patients with asymptomatic left ventricular dysfunction appear to predict all-cause and cardiovascular mortalities and development of clinical events related to the onset of heart failure or acute ischemic syndromes.
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Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis.
Ellen O. Weinberg,Frederick J. Schoen,Dorinda George,Yutaka Kagaya,Pamela S. Douglas,Sheldon E. Litwin,Heribert Schunkert,Claude R. Benedict,Beverly H. Lorell +8 more
TL;DR: In rats with ascending aortic stenosis, chronic ACE inhibition with fosinopril improved survival, decreased the extent of LV hypertrophy, and improved cardiac function despite persistent elevation of LV systolic pressure.
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New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA
TL;DR: It is concluded that TNK-TPA, given as a bolus, produces faster and more complete recanalization of occluded arteries in a rabbit experimental model compared with TPA, without increasing systemic plasmin generation or peripheral bleeding.