H
Haibo Jin
Researcher at Nanjing University
Publications - 13
Citations - 332
Haibo Jin is an academic researcher from Nanjing University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 6 publications receiving 52 citations.
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Journal ArticleDOI
Polystyrene microplastics induced male reproductive toxicity in mice
Haibo Jin,Tan Ma,Xiaoxuan Sha,Zhenyu Liu,Yuan Zhou,Xiannan Meng,Yabing Chen,Xiaodong Han,Jie Ding +8 more
TL;DR: It is demonstrated that PS-MPs induced male reproductive dysfunctions in mice, which provided new insights into the toxicity of MPs in mammals.
Journal ArticleDOI
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway
Haibo Jin,Minghao Yan,Chun Pan,Zhenyu Liu,Xiaoxuan Sha,Chengyue Jiang,Luxi Li,Mengge Pan,Dongmei Li,Xiaodong Han,Jie Ding +10 more
TL;DR: In this article , the effects of exposure to polystyrene microplastics (MPs) on the male reproductive system of mice were investigated and it was shown that chronic exposure to MPs resulted in toxicity of male reproduction under environmental exposure levels and these potential risks may ring alarm bells of public health.
Journal ArticleDOI
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway
Haibo Jin,Minghao Yan,Chun Pan,Zhenyu Liu,Xiaoxuan Sha,Chengyue Jiang,Luxi Li,Mengge Pan,Dongmei Li,Xiaodong Han,Jie Ding +10 more
TL;DR: In this article , the effects of exposure to polystyrene microplastic microplastics (MPs) on the male reproductive system of mice were investigated. And the results showed that chronic exposure to MPs resulted in toxicity of male reproduction under environmental exposure levels, which may ring alarm bells of public health.
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Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice
TL;DR: It is demonstrated that Microcystin-LR can stimulate intracellular Ca2+ and cAMP to activate PKC, PKA and MAPK signaling pathways in GnRH neurons, and then inhibit Pbx1a, Oct-1, Dlx-2, Otx-2 and upregulate c-Jun and c-Fos to initiate the transcription of GnRH, which provides novel insights to explore the mechanism associated with MC-LR-induced male reproductive barriers
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Maternal Exposure to Di-n-butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE2/MMP-2 in Mouse Offspring.
Tan Ma,Yuan Zhou,Yunhui Xia,Xiannan Meng,Haibo Jin,Bo Wang,Yusheng Chen,Jiayin Qiu,Jiang Wu,Jie Ding,Xiaodong Han,Dongmei Li +11 more
TL;DR: The data confirmed that maternal exposure to relative low-dose DBP promoted the formation of testicular TJs through down-regulation of NF-κB/COX-2/PGE2/MMP-2, which might promote the development of testis during puberty.