Haijing Yan

TL;DR: Autophagy was activated in the reperfusion phase, as revealed in both mice with middle cerebral artery occlusion and oxygen-glucose deprived cortical neurons in culture, and the protective role of autophagy during reperfusions may be attributable to mitophagy-related mitochondrial clearance and inhibition of downstream apoptosis.

TL;DR: It is demonstrated that the ER stress induced by tunicamycin and thapsigargin protects against the transient ischemic brain injury, and the PARK2-mediated mitophagy may be underlying the protection of ER stress.

TL;DR: H3R promotes I/R injury while its antagonism protects against ischaemic injury via histamine-independent mechanisms that involve suppressing H3R/CLIC4 binding-activated autophagy, suggesting that H3 R inhibition is a therapeutic target for cerebral ischaemia.

TL;DR: The aim of this study was to determine whether the carnosine‐histidine‐histamine pathway also played a protective role in subcortical ischemic vascular dementia (SIVD).

TL;DR: It is suggested that histamine up-regulates GLT-1 expression and function via astrocytic H1 receptors, thus resulting in neuroprotection against excitotoxicity and ischemic injury.