L
Lei Jiang
Researcher at Zhejiang University
Publications - 22
Citations - 941
Lei Jiang is an academic researcher from Zhejiang University. The author has contributed to research in topics: Neuroprotection & Ischemia. The author has an hindex of 12, co-authored 19 publications receiving 574 citations.
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Journal ArticleDOI
Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy
Xiangnan Zhang,Yang Yuan,Lei Jiang,Jing-ying Zhang,Jieqiong Gao,Zhe Shen,Yanrong Zheng,Tian Deng,Haijing Yan,Wen-Lu Li,Wei-Wei Hou,Jianxin Lu,Yao Shen,Hai-bing Dai,Weiwei Hu,Zhuohua Zhang,Zhong Chen +16 more
TL;DR: It is demonstrated that the ER stress induced by tunicamycin and thapsigargin protects against the transient ischemic brain injury, and the PARK2-mediated mitophagy may be underlying the protection of ER stress.
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BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2.
Yang Yuan,Yanrong Zheng,Xiangnan Zhang,Ying Chen,Xiaoli Wu,Jiaying Wu,Zhe Shen,Lei Jiang,Lu Wang,Wei Yang,Jianhong Luo,Zheng-Hong Qin,Weiwei Hu,Zhong Chen +13 more
TL;DR: The involvement of BNIP3L/NIX in cerebral ischemia-reperfusion (I-R)-induced mitophagy is identified and insights into mitochondrial quality control in ischemic stroke are offered.
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PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window
Zhe Shen,Yanrong Zheng,Jiaying Wu,Ying Chen,Xiaoli Wu,Yiting Zhou,Yang Yuan,Shou-sheng Lu,Lei Jiang,Zheng-Hong Qin,Zhong Chen,Weiwei Hu,Xiangnan Zhang +12 more
TL;DR: It is found that PARK2-dependent APC-induced mitophagy renders the brain resistant to ischemic injury, and APC treatment could be a favorable strategy to extend the thrombolytic time window for stroke therapy.
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Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo
Anil Ahsan,Yanrong Zheng,Xiaoli Wu,Wei-dong Tang,Mengru Liu,Shijia Ma,Lei Jiang,Weiwei Hu,Xiangnan Zhang,Zhong Chen +9 more
TL;DR: This work explored neuroprotection of Uro‐A against ischemic neuronal injury by activating mitophagy in mammal cells and Caenorhabditis elegans and found that mitochondrial autophagy clears damaged mitochondria and attenuates ischeMIC neuronal injury.
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Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury
Zhe Shen,Lei Jiang,Yang Yuan,Tian Deng,Yanrong Zheng,Yan-Yan Zhao,Wen-Lu Li,Jia-Ying Wu,Jian-Qing Gao,Weiwei Hu,Xiangnan Zhang,Zhong Chen +11 more
TL;DR: This work aimed to explore whether lactate is involved in ischemic injury via activating GPR81, an endogenous receptor for lactate, through activating G protein‐coupled receptor 81.